How can oscillatory neural circuits generate spatio-temporal activity patterns that are robust in the presence of noise yet flexible enough to provide specific, reproducible, adaptive responses to inputs? This problem is central to sensory processing as well as motor coordination. Our approach to this question involves a well-established and productive, interdisciplinary team from Biology, Physics and Nonlinear Dynamics. It combines nonlinear dynamical analysis, computational and electronic modeling, and neurophysiological studies of a tractable, oscillatory motor circuit from the crustacean stomatogastric system. Specifically, we ask: How do particular membrane properties, synaptic strengths and kinetics, and circuit architectures contribute to the production of multiple, stable and controllable patterns? How do these characteristics, and their modulation, affect dynamical responses to noise and control signals?

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
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Chen, Daofen
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University of California San Diego
Schools of Arts and Sciences
La Jolla
United States
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Abarbanel, Henry D I; Creveling, Daniel R; Jeanne, James M (2008) Estimation of parameters in nonlinear systems using balanced synchronization. Phys Rev E Stat Nonlin Soft Matter Phys 77:016208
Nowotny, Thomas; Szucs, Attila; Pinto, Reynaldo D et al. (2006) StdpC: a modern dynamic clamp. J Neurosci Methods 158:287-99
Szucs, Attila; Selverston, Allen I (2006) Consistent dynamics suggests tight regulation of biophysical parameters in a small network of bursting neurons. J Neurobiol 66:1584-601
Briggman, Kevin L; Abarbanel, Henry D I; Kristan Jr, William B (2006) From crawling to cognition: analyzing the dynamical interactions among populations of neurons. Curr Opin Neurobiol 16:135-44
Briggman, K L; Abarbanel, H D I; Kristan Jr, W B (2005) Optical imaging of neuronal populations during decision-making. Science 307:896-901
Abarbanel, Henry D I; Talathi, Sachin S; Gibb, Leif et al. (2005) Synaptic plasticity with discrete state synapses. Phys Rev E Stat Nonlin Soft Matter Phys 72:031914
Szucs, Attila; Abarbanel, Henry D I; Rabinovich, Michail I et al. (2005) Dopamine modulation of spike dynamics in bursting neurons. Eur J Neurosci 21:763-72
Denker, Michael; Szucs, Attila; Pinto, Reynaldo D et al. (2005) A network of electronic neural oscillators reproduces the dynamics of the periodically forced pyloric pacemaker group. IEEE Trans Biomed Eng 52:792-8
Selverston, Allen I (2005) A neural infrastructure for rhythmic motor patterns. Cell Mol Neurobiol 25:223-44
Abarbanel, Henry D I; Gibb, Leif; Mindlin, Gabriel B et al. (2004) Spike timing and synaptic plasticity in the premotor pathway of birdsong. Biol Cybern 91:159-67

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