Both acute and chronic stress can have long-term physiological and psychological consequences, some of which can be ameliorated through positive social interaction. The current proposal will examine the effects of prior exposure to positive social interaction versus social stress on the histological, physiological and behavioral consequences of experimental stroke. In addition, alterations in the corticosteroid, glutamate and antioxidant responses to experimental stroke will be examined as possible mechanisms through which social cues can influence histological and functional outcome in this model. The data collected as part Of this proposal will increase our understanding of the basic pathophysiological mechanism of cerebral ischemia and the roles that social interaction and the hypothalamic-pituitary-adrenal axis play in modulating excitotoxic neuronal death. Ultimately, understanding the factors that modulate neurotoxicity and behavioral outcomes may facilitate the development of therapeutic approaches for the prevention and treatment of cerebral ischemia. Taken together, the proposed studies will provide a neurobiological foundation on which to study the effects of social cues on experimental stroke outcome, and may provide insights into the mechanisms underlying individual differences in outcome following an ischemic event.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Special Emphasis Panel (ZRG1-BBBP-2 (01))
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Marler, John R
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Johns Hopkins University
Schools of Medicine
United States
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Karelina, Kate; Stuller, Kathleen A; Jarrett, Brant et al. (2011) Oxytocin mediates social neuroprotection after cerebral ischemia. Stroke 42:3606-11
Karelina, Kate; DeVries, A Courtney (2011) Modeling social influences on human health. Psychosom Med 73:67-74
Neigh, Gretchen N; Karelina, Kate; Glasper, Erica R et al. (2009) Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline. Stroke 40:3601-7
Karelina, Kate; Norman, Gregory J (2009) Oxytocin Influence on NTS: Beyond Homeostatic Regulation. J Neurosci 29:4687-4689
Weil, Zachary M; Karelina, Kate; Su, Alan J et al. (2009) Time-of-day determines neuronal damage and mortality after cardiac arrest. Neurobiol Dis 36:352-60
Weil, Zachary M; Norman, Greg J; DeVries, A Courtney et al. (2009) Photoperiod alters autonomic regulation of the heart. Proc Natl Acad Sci U S A 106:4525-30
Karelina, Kate; Norman, Greg J; Zhang, Ning et al. (2009) Social isolation alters neuroinflammatory response to stroke. Proc Natl Acad Sci U S A 106:5895-900
Weil, Zachary M; Norman, Greg J; Karelina, Kate et al. (2009) Sleep deprivation attenuates inflammatory responses and ischemic cell death. Exp Neurol 218:129-36
Weil, Zachary M; Norman, Greg J; DeVries, A Courtney et al. (2008) The injured nervous system: a Darwinian perspective. Prog Neurobiol 86:48-59
DeVries, A Courtney; Craft, Tara K S; Glasper, Erica R et al. (2007) 2006 Curt P. Richter award winner: Social influences on stress responses and health. Psychoneuroendocrinology 32:587-603

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