Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS042257-01A2S1
Application #
6784374
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Utz, Ursula
Project Start
2002-12-15
Project End
2005-11-30
Budget Start
2002-12-15
Budget End
2003-11-30
Support Year
1
Fiscal Year
2003
Total Cost
$47,000
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Neurology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Chearwae, Wanida; Bright, John J (2008) 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol 28:558-70
Mo, Caiqing; Chearwae, Wanida; O'Malley, John T et al. (2008) Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J Immunol 181:5681-90
Rajasingh, Johnson; Bright, John J (2006) 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. Exp Cell Res 312:2538-46
Muthian, Gladson; Raikwar, Himanshu P; Rajasingh, Johnson et al. (2006) 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis. J Neurosci Res 83:1299-309
Rajasingh, Johnson; Raikwar, Himanshu P; Muthian, Gladson et al. (2006) Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem Biophys Res Commun 340:359-68
Raikwar, Himanshu P; Muthian, Gladson; Rajasingh, Johnson et al. (2006) PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. J Neuroimmunol 178:76-86
Muthian, Gladson; Pradeep, Chellappan G; Sargapradeep, Kuttappan et al. (2006) Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response. Exp Parasitol 114:193-203
Muthian, Gladson; Raikwar, Himanshu P; Johnson, Caroline et al. (2006) COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis. J Clin Immunol 26:73-85
Raikwar, Himanshu P; Muthian, Gladson; Rajasingh, Johnson et al. (2005) PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis. J Neuroimmunol 167:99-107
Muthian, Gladson; Bright, John J (2004) Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. J Clin Immunol 24:542-52

Showing the most recent 10 out of 14 publications