Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS042273-02
Application #
6685926
Study Section
Special Emphasis Panel (ZRG1-BDCN-1 (25))
Program Officer
Jacobs, Tom P
Project Start
2002-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$298,300
Indirect Cost
Name
Thomas Jefferson University
Department
Emergency Medicine
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Chen-Roetling, Jing; Liu, Wenpei; Regan, Raymond F (2012) Hemopexin decreases hemin accumulation and catabolism by neural cells. Neurochem Int 60:488-94
Chen-Roetling, Jing; Sinanan, Jesse; Regan, Raymond F (2012) Effect of iron chelators on methemoglobin and thrombin preconditioning. Transl Stroke Res 3:452-9
Chen-Roetling, Jing; Liu, Wenpei; Regan, Raymond F (2011) Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin. Free Radic Biol Med 51:1966-74
Chen-Roetling, Jing; Chen, Lifen; Regan, Raymond F (2011) Apotransferrin protects cortical neurons from hemoglobin toxicity. Neuropharmacology 60:423-31
Chen, Lifen; Zhang, Xuefeng; Chen-Roetling, Jing et al. (2011) Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg 114:1159-67
Jaremko, Kellie M; Chen-Roetling, Jing; Chen, Lifen et al. (2010) Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures. J Neurochem 114:1063-73
Chen, Mai; Awe, Olatilewa O; Chen-Roetling, Jing et al. (2010) Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage. Brain Res 1337:95-103
Chen-Roetling, Jing; Chen, Lifen; Regan, Raymond F (2009) Minocycline attenuates iron neurotoxicity in cortical cell cultures. Biochem Biophys Res Commun 386:322-6
Li, Zhi; Chen-Roetling, Jing; Regan, Raymond F (2009) Increasing expression of H- or L-ferritin protects cortical astrocytes from hemin toxicity. Free Radic Res 43:613-21
Regan, Raymond F; Chen, Mai; Li, Zhi et al. (2008) Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. Neurobiol Dis 31:242-9

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