This ARRA application represents an extension of RO1-44351, the first prospective cohort investigation of children with new onset epilepsy designed to characterize the etiology and natural history of neurodevelopmental abnormalities in cognition, brain structure, and psychopathology. Our long term goal is to understand the causes and earliest risk factors predictive of adverse quality of life outcomes of childhood onset epilepsy. This combined cross-sectional and longitudinal cohort study involves: a) a 6 year follow up of cognition, brain structure, and mental health of the initial cohort (75 children with new onset epilepsy and 62 healthy controls), b) enrichment of the cohort with 75 children with new onset epilepsy and 62 healthy controls, and c) the addition of new neuroimaging and cognitive procedures designed to address hypotheses regarding the neurobiology of critical cognitive and neurobehavioral comorbidities as well as the impact of epilepsy on cognitive and brain development.
The specific aims of this application are: 1) Characterize the long term (6 year) course of cognitive development, brain maturation, and psychopathology associated with neurobehavioral comorbidities in new onset childhood epilepsy. 2) Identify the unique abnormalities in cortical morphology associated with neurobehavioral comorbidities in new onset epilepsy. 3) Characterize abnormalities in baseline cerebral white matter and the clinical significance of identified abnormalities in new onset epilepsy. 2.

Public Health Relevance

Childhood epilepsy is a common disorder that is frequently complicated by cognitive and psychiatric comorbidities that adversely affect quality of life. The purpose of this prospective cohort investigation is to better understand the cause, course and long term implications of two frequent comorbidities of childhood epilepsy (Attention Deficit Hyperactivity Disorder, Academic Problems).

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Developmental Brain Disorders Study Section (DBD)
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Fureman, Brandy E
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University of Wisconsin Madison
Schools of Medicine
United States
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Garcia-Ramos, Camille; Dabbs, Kevin; Lin, Jack J et al. (2018) Progressive dissociation of cortical and subcortical network development in children with new-onset juvenile myoclonic epilepsy. Epilepsia 59:2086-2095
Garcia-Ramos, Camille; Dabbs, Kevin; Meyerand, Elizabeth et al. (2018) Psychomotor slowing is associated with anomalies in baseline and prospective large scale neural networks in youth with epilepsy. Neuroimage Clin 19:222-231
Srnka, Kyle; Seidenberg, Michael; Hermann, Bruce et al. (2018) Intraindividual variability in attentional vigilance in children with epilepsy. Epilepsy Behav 79:42-45
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Hermann, Bruce; Loring, David W; Wilson, Sarah (2017) Paradigm Shifts in the Neuropsychology of Epilepsy. J Int Neuropsychol Soc 23:791-805
Garcia-Ramos, Camille; Bobholz, Sam; Dabbs, Kevin et al. (2017) Brain structure and organization five decades after childhood onset epilepsy. Hum Brain Mapp 38:3289-3299
Hanson, Melissa; Morrison, Blaise; Jones, Jana E et al. (2017) Control groups in paediatric epilepsy research: do first-degree cousins show familial effects? Epileptic Disord 19:49-58
Garcia-Ramos, Camille; Lin, Jack J; Bonilha, Leonardo et al. (2016) Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy. Neuroimage Clin 12:815-824
Jones, Jana E; Siddarth, Prabha; Almane, Dace et al. (2016) Identification of risk for severe psychiatric comorbidity in pediatric epilepsy. Epilepsia 57:1817-1825
La, Christian; Garcia-Ramos, Camille; Nair, Veena A et al. (2016) Age-Related Changes in BOLD Activation Pattern in Phonemic Fluency Paradigm: An Investigation of Activation, Functional Connectivity and Psychophysiological Interactions. Front Aging Neurosci 8:110

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