Cognitive, academic, social and psychiatric abnormalities are common in childhood onset epilepsy, with enduring adverse consequences into adulthood, even among those with uncomplicated and remitted epilepsies. To understand the natural history of these lifespan issues, the initial funding cycle of our prospective cohort study (RO1-44351) examined children (ages 8-18) with newly diagnosed idiopathic epilepsies (n=75) and healthy controls (n=62), and followed them for 2 years with neuropsychological, psychiatric, and neuroimaging techniques. While informing the early natural history of cognitive, anatomic, and psychiatric abnormalities of childhood epilepsy, we also identified risk factors at the time of epilepsy diagnosis that predicted developmental trajectories two years following diagnosis. We hypothesize these same abnormalities will predict longer term outcomes in important areas of life performance (e.g., employment, independent living, educational attainment). In this competing renewal application, we propose to follow our original cohort to characterize and predict young adulthood outcomes, enrich the cohort with new onset epilepsy and control participants (n=150), and incorporate new procedures to test hypotheses regarding the effects of family history, disrupted neural circuitry, and epilepsy syndrome on life course.
The specific aims of this competing renewal application are as follows: 1) Characterize the longer-term (10- year) social, educational, vocational, and psychiatric trajectories of childhood onset epilepsy and identify predictors of favorable and unfavorable young adult outcomes;2) Clarify the role of family history to the presence of cognitive and psychiatric comorbidities in children with new onset epilepsy;3) Characterize the relationship between abnormalities in brain volume, shape and connectivity with disordered cognition and psychiatric status;and 4) Identify syndrome-specific cognitive, psychiatric, and imaging abnormalities.

Public Health Relevance

Childhood epilepsy is a prevalent neurological disorder associated with poor outcomes in key aspects of adult life (e.g., employment and finances;marriage and family;social and psychiatric status), but the predictors of these outcomes remain poorly understood. The results of this controlled prospective cohort investigation will provide what we believe are the earliest insights into the natural history of these problematic lifespan outcomes.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01NS044351-10
Application #
8736015
Study Section
Developmental Brain Disorders Study Section (DBD)
Program Officer
Fureman, Brandy E
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Madison
State
WI
Country
United States
Zip Code
53715
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Almane, Dace; Jones, Jana E; Jackson, Daren C et al. (2014) The social competence and behavioral problem substrate of new- and recent-onset childhood epilepsy. Epilepsy Behav 31:91-6
Rathouz, Paul J; Zhao, Qianqian; Jones, Jana E et al. (2014) Cognitive development in children with new onset epilepsy. Dev Med Child Neurol 56:635-41
Asato, Miya R; Caplan, Rochelle; Hermann, Bruce P (2014) Epilepsy and comorbidities -what are we waiting for? Epilepsy Behav 31:127-8
Bonilha, Leonardo; Tabesh, Ali; Dabbs, Kevin et al. (2014) Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy. Hum Brain Mapp 35:3661-72
Saute, Ricardo; Dabbs, Kevin; Jones, Jana E et al. (2014) Brain morphology in children with epilepsy and ADHD. PLoS One 9:e95269
Jackson, Daren C; Lin, Jack J; Chambers, Karlee L et al. (2014) Birth weight and cognition in children with epilepsy. Epilepsia 55:901-8
Dabbs, Kevin; Jones, Jana E; Jackson, Daren C et al. (2013) Patterns of cortical thickness and the Child Behavior Checklist in childhood epilepsy. Epilepsy Behav 29:198-204
Amarreh, Ishmael; Dabbs, Kevin; Jackson, Daren C et al. (2013) Cerebral white matter integrity in children with active versus remitted epilepsy 5 years after diagnosis. Epilepsy Res 107:263-71
Jackson, Daren C; Dabbs, Kevin; Walker, Natalie M et al. (2013) The neuropsychological and academic substrate of new/recent-onset epilepsies. J Pediatr 162:1047-53.e1

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