The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain. Responses within different areas of primary somatosensory cortex (SI) will be examined (areas 3a, 3b, 1, and 2). Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics.
The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain, in particular in the primary somatosensory cortex (SI). These studies will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics.
|Chernov, Mykyta M; Chen, Gang; Torre-Healy, Luke A et al. (2016) Microelectrode array stimulation combined with intrinsic optical imaging: A novel tool for functional brain mapping. J Neurosci Methods 263:7-14|
|Roe, Anna Wang; Chernov, Mykyta M; Friedman, Robert M et al. (2015) In Vivo Mapping of Cortical Columnar Networks in the Monkey with Focal Electrical and Optical Stimulation. Front Neuroanat 9:135|
|Cayce, Jonathan M; Friedman, Robert M; Chen, Gang et al. (2014) Infrared neural stimulation of primary visual cortex in non-human primates. Neuroimage 84:181-90|
|Ashaber, Mária; Pálfi, Emese; Friedman, Robert M et al. (2014) Connectivity of somatosensory cortical area 1 forms an anatomical substrate for the emergence of multifinger receptive fields and complex feature selectivity in the squirrel monkey (Saimiri sciureus). J Comp Neurol 522:1769-85|
|Chernov, Mykyta Mikhailovich; Chen, Gang; Roe, Anna Wang (2014) Histological assessment of thermal damage in the brain following infrared neural stimulation. Brain Stimul 7:476-82|
|Brock, Andrea A; Friedman, Robert M; Fan, Reuben H et al. (2013) Optical imaging of cortical networks via intracortical microstimulation. J Neurophysiol 110:2670-8|
|Wang, Zheng; Chen, Li Min; Négyessy, László et al. (2013) The relationship of anatomical and functional connectivity to resting-state connectivity in primate somatosensory cortex. Neuron 78:1116-26|
|Ruiz, Octavio; Lustig, Brian R; Nassi, Jonathan J et al. (2013) Optogenetics through windows on the brain in the nonhuman primate. J Neurophysiol 110:1455-67|
|Wang, Zheng; Qi, Hui-Xin; Kaas, Jon H et al. (2013) Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys. Exp Neurol 249:132-43|
|Négyessy, László; Pálfi, Emese; Ashaber, Mária et al. (2013) Intrinsic horizontal connections process global tactile features in the primary somatosensory cortex: neuroanatomical evidence. J Comp Neurol 521:2798-817|
Showing the most recent 10 out of 23 publications