The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain. Responses within different areas of primary somatosensory cortex (SI) will be examined (areas 3a, 3b, 1, and 2). Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics.

Public Health Relevance

The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain, in particular in the primary somatosensory cortex (SI). These studies will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS044375-09S1
Application #
8514859
Study Section
Somatosensory and Chemosensory Systems Study Section (SCS)
Program Officer
Gnadt, James W
Project Start
2002-07-01
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
9
Fiscal Year
2012
Total Cost
$38,835
Indirect Cost
$13,941
Name
Vanderbilt University Medical Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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