We propose to study prospectively the relationships between lifestyle factors and risk of amyotrophic lateral sclerosis (ALS) among participants in the Cancer Prospective Study II (CPS II) of the American Cancer Society. The original cohort comprised 1,184,622 men and women from all 50 United States, the District of Columbia, and Puerto Rico, aged 30 years and older, who completed a lifestyle and dietary questionnaire in 1982. The proposed investigation will include the 1,098,726 participants who were alive on January 1, 1989, as reliable information on causes of death is only available after this date. During ten years of follow-up, 621 participants in this cohort died of ALS. Specifically, we will examine prospectively the associations between risk of ALS and cigarette smoking, use of antioxidant vitamins, education, occupation, and exposures to agricultural chemicals and solvents. Because of the large number of participants and long follow-up time this cohort provides a unique opportunity to examine prospectively the association between lifestyle variables and the risk of ALS among men and women. A further strength of the proposed investigation is the availability of information on several potential confounders, including past medical history, physical activity, and diet. Identification of the risk factors for ALS will provide clues about the etiology of the disease and contribute to identify those hypotheses that need more intense scrutiny in clinical or laboratory investigations.
| O'Reilly, Éilis J; Bjornevik, Kjetil; Schwarzschild, Michael A et al. (2018) Pre-diagnostic plasma urate and the risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 19:194-200 |
| O'Reilly, ÉIlis J; Liu, Dawei; Johns, Donald R et al. (2017) Serum urate at trial entry and ALS progression in EMPOWER. Amyotroph Lateral Scler Frontotemporal Degener 18:120-125 |
| Hagan, Kaitlin A; Munger, Kassandra L; Ascherio, Alberto et al. (2016) Epidemiology of Major Neurodegenerative Diseases in Women: Contribution of the Nurses' Health Study. Am J Public Health 106:1650-5 |
| Ascherio, Alberto; O'Reilly, Eilis Joan (2016) New insights on physical activity and amyotrophic lateral sclerosis. Eur J Epidemiol 31:213-5 |
| Fondell, Elinor; O'Reilly, Eilis J; Fitzgerald, Kathryn C et al. (2014) Dietary fiber and amyotrophic lateral sclerosis: results from 5 large cohort studies. Am J Epidemiol 179:1442-9 |
| Fitzgerald, Kathryn C; O'Reilly, Éilis J; Falcone, Guido J et al. (2014) Dietary ?-3 polyunsaturated fatty acid intake and risk for amyotrophic lateral sclerosis. JAMA Neurol 71:1102-10 |
| Fondell, Elinor; O'Reilly, Eilis J; Fitzgerald, Kathryn C et al. (2013) Magnesium intake and risk of amyotrophic lateral sclerosis: results from five large cohort studies. Amyotroph Lateral Scler Frontotemporal Degener 14:356-61 |
| O'Reilly, Éilis J; Wang, Hao; Weisskopf, Marc G et al. (2013) Premorbid body mass index and risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 14:205-11 |
| Fitzgerald, Kathryn C; O'Reilly, Eilis J; Fondell, Elinor et al. (2013) Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies. Ann Neurol 73:236-45 |
| Fondell, Elinor; O'Reilly, Eilis J; Fitzgerald, Kathryn C et al. (2012) Non-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: results from five prospective cohort studies. Amyotroph Lateral Scler 13:573-9 |
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