Extended periods of waking result in cognitive impairments in humans, rats, and flies. Sleep homeostasis, the increase in sleep observed following sleep loss, is believed to counter the negative effects of prolonged waking by restoring vital biological processes that are degraded during sleep deprivation. Unfortunately, precisely which processes need restoration remains a matter of speculation and debate. Given that sleep disturbances are increasingly recognized as contributing to cognitive impairment in patients with neurological disorders, identifying pathways that are degraded during waking and restored during sleep may enhance our ability to understand neuronal processes during both health and disease. We have found that short-term memory deficits resulting from sleep loss can be reversed during sleep deprivation to a level only observed following a full night's sleep. Specifically, functional restoration of short-term memory can be achieved in an otherwise wake, behaving animal by altering a single neuronal structure. With that in mind, we will evaluate the role of sleep loss on both the acquisition of short-term memory and the ability to consolidate long-term memories (LTM) after post-training sleep deprivation. We hypothesize that genes that prevent declines in short-term memory during sleep deprivation and/or preserve the ability to consolidate long-term memories LTM after post- training sleep deprivation are strong candidates for playing a role in sleep restoration.
Sleep disturbances are increasingly recognized as contributing to cognitive impairment in patients with neurological disorders. Identifying pathways that are degraded during waking and restored during sleep may enhance our ability to understand neuronal processes during both health and disease.
|Dissel, Stephane; Seugnet, Laurent; Thimgan, Matthew S et al. (2015) Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption. Brain Behav Immun 47:75-85|
|Donlea, Jeffrey M; Ramanan, Narendrakumar; Silverman, Neal et al. (2014) Genetic rescue of functional senescence in synaptic and behavioral plasticity. Sleep 37:1427-37|
|Thimgan, Matthew S; Gottschalk, Laura; Toedebusch, Cristina et al. (2013) Cross-translational studies in human and Drosophila identify markers of sleep loss. PLoS One 8:e61016|
|Vanderheyden, William M; Gerstner, Jason R; Tanenhaus, Anne et al. (2013) ERK phosphorylation regulates sleep and plasticity in Drosophila. PLoS One 8:e81554|
|Donlea, Jeffrey; Leahy, Averi; Thimgan, Matthew S et al. (2012) Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila. Proc Natl Acad Sci U S A 109:2613-8|
|Seugnet, Laurent; Suzuki, Yasuko; Donlea, Jeff M et al. (2011) Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila. Sleep 34:137-46|
|Donlea, Jeffrey M; Thimgan, Matthew S; Suzuki, Yasuko et al. (2011) Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science 332:1571-6|
|Seugnet, Laurent; Suzuki, Yasuko; Merlin, Gabriel et al. (2011) Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila. Curr Biol 21:835-40|
|Thimgan, Matthew S; Suzuki, Yasuko; Seugnet, Laurent et al. (2010) The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss. PLoS Biol 8:|
|Donlea, Jeffrey M; Ramanan, Narendrakumar; Shaw, Paul J (2009) Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324:105-8|
Showing the most recent 10 out of 17 publications