The primary focus is to examine the neurophysiologic basis of the respiratory-motor coupling and to rule out potential alternatives. We hypothesize that there is a finger flexion-expiration, finger extension-inspiration coupling. The neurophysiologic basis for this coupling is that forced expiration enhances corticospinal excitability for the finger flexors and finger extensors, while forced inspiration enhances activation primarily for the finger extensors. To test the hypothesis, we will quantify changes in corticospinal excitability associated with voluntary breathing (Aim 1) using transcranial magnetic stimulation (TMS) and neuromuscular electrical stimulation (ES) in a variety of tasks in normal subjects.
In Aim 2, we will investigate potential alternative mechanisms that the voluntary breathing effects are artifacts of mechanical transfer or of dual tasking. Collectively, outcomes of this project are likely to provide evidence for the intrinsic neurophysiologic basis of the finger flexion-expiration, finger extension-inspiration coupling. The long-term goal is to apply the intrinsic physiological coupling between voluntary breathing and finger muscles to rehabilitation of finger extension impairment after stroke, e.g. electrical stimulation delivered to the finger extensors on the inspiratory phase of voluntary breathing is expected to maximize the stimulation effect.

Public Health Relevance

The proposed research examines underlying neurophysiologic mechanisms of the respiratory-motor coupling using non-invasive tools will be used, such as transcranial magnetic stimulation (TMS) and neuromuscular electrical stimulation (ES). The potential alternative mechanisms will be ruled out. Potential clinical applications of this newly discovered phenomenon for stroke rehabilitation are demonstrated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS060774-05
Application #
8298646
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Chen, Daofen
Project Start
2008-08-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$225,095
Indirect Cost
$75,032
Name
University of Texas Health Science Center Houston
Department
None
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Li, Sheng; Durand-Sanchez, Ana; Latash, Mark L (2014) Inter-limb force coupling is resistant to distorted visual feedback in chronic hemiparetic stroke. J Rehabil Med 46:206-11
Hampton, Stephen; Armstrong, Gina; Ayyar, Monika Shah et al. (2014) Quantification of perceived exertion during isometric force production with the Borg scale in healthy individuals and patients with chronic stroke. Top Stroke Rehabil 21:33-9
Li, Sheng; Liu, Jie; Bhadane, Minal et al. (2014) Activation deficit correlates with weakness in chronic stroke: evidence from evoked and voluntary EMG recordings. Clin Neurophysiol 125:2413-7
Li, Shengai; Hu, Tracy; Beran, Maria A et al. (2014) Habituation to experimentally induced electrical pain during voluntary-breathing controlled electrical stimulation (BreEStim). PLoS One 9:e104729
Li, Sheng; Chang, Shuo-Hsiu; Francisco, Gerard E et al. (2014) Acoustic startle reflex in patients with chronic stroke at different stages of motor recovery: a pilot study. Top Stroke Rehabil 21:358-70
Park, Woo-Hyung; Li, Sheng (2013) Responses of finger flexor and extensor muscles to transcranial magnetic stimulation during isometric force production tasks. Muscle Nerve 48:739-44
Chang, Shuo-Hsiu; Francisco, Gerard E; Zhou, Ping et al. (2013) Spasticity, weakness, force variability, and sustained spontaneous motor unit discharges of resting spastic-paretic biceps brachii muscles in chronic stroke. Muscle Nerve 48:85-92
Li, Sheng (2013) Analysis of increasing and decreasing isometric finger force generation and the possible role of the corticospinal system in this process. Motor Control 17:221-37
Li, Sheng (2013) Breathing-controlled Electrical Stimulation (BreEStim) for management of neuropathic pain and spasticity. J Vis Exp :e50077
Chang, Shuo-Hsiu; Durand-Sanchez, Ana; Ditommaso, Craig et al. (2013) Interlimb interactions during bilateral voluntary elbow flexion tasks in chronic hemiparetic stroke. Physiol Rep 1:e00010

Showing the most recent 10 out of 14 publications