Stroke is a disease with tremendous individual, family, and societal impact. It is the number one cause of adult disability and third leading cause of death in the United States. Between now and the year 2050, the cost of stroke in the United States will exceed 2 trillion dollars. There is a tremendous ethnic disparity with respect to stroke in the United States. Mexican Americans are much more likely to have a stroke compared with European Americans. In Mexican Americans strokes occur at younger ages, are more likely to recur and have the same severity as they do in European Americans. Mexican Americans are the overwhelming largest sub- population of Hispanic Americans, the nation's largest minority group. This proposal, a scientifically-based rigorous behavioral education intervention trial, seeks to aggressively prevent stroke, especially in Mexican Americans. Faith and family are strong components of Mexican American culture. This project works with these positive fundamental elements in order to affect stroke prevention. This project will take place in Nueces County, Texas. The project investigators have worked in this community for the past 14 years and have published extensively regarding the stroke health disparity in this stable, non-immigrant community of Mexican Americans and European Americans. We have established a strong partnership with the Catholic Diocese of Corpus Christi and assembled a team with tremendous experience at successful health behavior intervention research. Together, a proposal has been crafted that will directly speak to aggressive stroke risk factor reduction in Mexican Americans and European Americans in this representative United States community. The significance of such research is tremendous. As the Mexican American population grows and ages, the stroke impact will be felt with greater and greater intensity. Now is the time to develop aggressive, scientifically tested interventions to limit the burden of this disease on this important segment of the United States population, and to reduce the costs of this disease to the country as a whole, in keeping with the Government Performance and Results Act (GPRA) goal to """"""""identify culturally appropriate, effective stroke prevention programs for nationwide implementation in minority communities"""""""" by FY2010.

Public Health Relevance

Mexican Americans, the largest sub-population of Hispanic Americans, the nation's largest minority group, have a higher risk of stroke than non-Hispanic whites. This proposal seeks to reduce stroke risk, especially in Mexican Americans, through a scientifically-based rigorous behavioral intervention trial. The public health impact of successful stroke prevention programs is enormous as stroke represents the number 3 killer and number one cause of disability in the United States.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-RPHB-K (50))
Program Officer
Waddy, Salina P
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Callaghan, Brian C; Kerber, Kevin A; Banerjee, Mousumi et al. (2016) The evaluation of distal symmetric polyneuropathy: utilisation and expenditures by community neurologists. J Neurol Neurosurg Psychiatry 87:113-4
Morgenstern, Lewis B; Sánchez, Brisa N; Conley, Kathleen M et al. (2016) The Association between Changes in Behavioral Risk Factors for Stroke and Changes in Blood Pressure. J Stroke Cerebrovasc Dis 25:2116-21
Brown, Devin L; Conley, Kathleen M; Sánchez, Brisa N et al. (2015) A Multicomponent Behavioral Intervention to Reduce Stroke Risk Factor Behaviors: The Stroke Health and Risk Education Cluster-Randomized Controlled Trial. Stroke 46:2861-7
Kerber, Kevin A; Meurer, William J; Brown, Devin L et al. (2015) Stroke risk stratification in acute dizziness presentations: A prospective imaging-based study. Neurology 85:1869-78
Johnson, Dayna A; Brown, Devin L; Morgenstern, Lewis B et al. (2015) The association of neighborhood characteristics with sleep duration and daytime sleepiness. Sleep Health 1:148-155
Lisabeth, Lynda D; Sánchez, Brisa N; Baek, Jonggyu et al. (2014) Neurological, functional, and cognitive stroke outcomes in Mexican Americans. Stroke 45:1096-101
Kelly, Adam G; Zahuranec, Darin B; Holloway, Robert G et al. (2014) Variation in do-not-resuscitate orders for patients with ischemic stroke: implications for national hospital comparisons. Stroke 45:822-7
Woo, Daniel; Falcone, Guido J; Devan, William J et al. (2014) Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet 94:511-21
Burke, James F; Skolarus, Lesli E; Adelman, Eric E et al. (2014) Influence of hospital-level practices on readmission after ischemic stroke. Neurology 82:2196-204
Callaghan, Brian C; Kerber, Kevin A; Lisabeth, Lynda L et al. (2014) Role of neurologists and diagnostic tests on the management of distal symmetric polyneuropathy. JAMA Neurol 71:1143-9

Showing the most recent 10 out of 22 publications