The objectives of this research are: (i) validation of "in-vivo animation of event-related gamma-oscillations on electrocorticography (ECoG)" as a language mapping method for children who undergo brain surgeries, and (ii) better understanding of the human language system. About 1% of the general population has epilepsy;one-fifth of epilepsy in children is medically intractable;subsets of children with intractable focal epilepsy benefit from surgical resection of the epileptogenic zone. Brain tumor is often associated with focal epilepsy in children, and surgical resection of tumor together with the epileptogenic focus is indicated in such children. The goals of both epilepsy and brain tumor surgeries include identification and preservation of the eloquent cortices such as the language cortex. However, conventional brain mapping using electrical stimulation lacks sufficient sensitivity to identify the language areas in children under age 10 years, often takes several hours to complete, and has a risk of stimulation-induced seizures. Thus, alternative language mapping techniques would be highly desirable in these children. We have recently developed a novel language mapping method which we refer to as "in-vivo animation of event-related gamma-oscillations". This new and innovative method appears promising for language mapping in children. As the next step, we will validate this mapping method using electrical stimulation and postoperative neuropsychological testing in this project. Specifically, we will determine whether brief auditory-language tasks will successively delineate gamma augmentation in the cortical sites responsible for receptive language function, expressive language function and overt speech. We will also determine whether a visual-language task will successively delineate gamma augmentation in the cortical sites responsible for receptive language function and expressive language function. Innovation in our project includes: (i) the study focusing on young subjects across a wide range of age (5 - 20 years), in about 40% of whom identification of the language cortex is difficult using electrical stimulation, (ii) in-vivo animation of cortical activation on an individual three-dimensional MRI with a good temporal resolution [10 msec] and a good spatial resolution [1 cm], and (iii) assessment of ECoG signals least affected by artifacts derived from overt speech tasks. This project is clinically significant since the results will be directly translatable into patient management and our event-related ECoG analysis has the potential to become a mainstream language mapping method which is less-invasive, more time-efficient, and more patient-friendly compared to the currently used electrical stimulation method.

Public Health Relevance

The goals of this research are (i) validation of the new mapping technique: "in-vivo animation of language- induced gamma oscillations on electrocorticography" as a new diagnostic tool for children who undergo brain surgeries and (ii) better understanding of the human language system. We will apply brief language tasks to children who undergo brain surgeries and identify the language-related brain areas, which are otherwise difficult to localize using the conventional electrical stimulation method. The results will introduce a novel, more time-efficient and patient-friendly language mapping method and are expected to improve the language outcome after brain surgeries in children.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Developmental Brain Disorders Study Section (DBD)
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Fureman, Brandy E
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Wayne State University
Schools of Medicine
United States
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Ueda, Keisuke; Brown, Erik C; Kojima, Katsuaki et al. (2015) Mapping mental calculation systems with electrocorticography. Clin Neurophysiol 126:39-46
Cho-Hisamoto, Yoshimi; Kojima, Katsuaki; Brown, Erik C et al. (2015) Gamma activity modulated by naming of ambiguous and unambiguous images: intracranial recording. Clin Neurophysiol 126:17-26
Brown, Erik C; Muzik, Otto; Rothermel, Robert et al. (2014) Evaluating signal-correlated noise as a control task with language-related gamma activity on electrocorticography. Clin Neurophysiol 125:1312-23
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Kojima, Katsuaki; Brown, Erik C; Matsuzaki, Naoyuki et al. (2013) Gamma activity modulated by picture and auditory naming tasks: intracranial recording in patients with focal epilepsy. Clin Neurophysiol 124:1737-44
Kojima, Katsuaki; Brown, Erik C; Rothermel, Robert et al. (2013) Clinical significance and developmental changes of auditory-language-related gamma activity. Clin Neurophysiol 124:857-69
Jeong, Jeong-Won; Asano, Eishi; Brown, Erik C et al. (2013) Automatic detection of primary motor areas using diffusion MRI tractography: comparison with functional MRI and electrical stimulation mapping. Epilepsia 54:1381-90
Govindan, Rajkumar Munian; Asano, Eishi; Juhasz, Csaba et al. (2013) Surface-based laminar analysis of diffusion abnormalities in cortical and white matter layers in neocortical epilepsy. Epilepsia 54:667-77

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