The objectives of this research are: (i) validation of "in-vivo animation of event-related gamma-oscillations on electrocorticography (ECoG)" as a language mapping method for children who undergo brain surgeries, and (ii) better understanding of the human language system. About 1% of the general population has epilepsy;one-fifth of epilepsy in children is medically intractable;subsets of children with intractable focal epilepsy benefit from surgical resection of the epileptogenic zone. Brain tumor is often associated with focal epilepsy in children, and surgical resection of tumor together with the epileptogenic focus is indicated in such children. The goals of both epilepsy and brain tumor surgeries include identification and preservation of the eloquent cortices such as the language cortex. However, conventional brain mapping using electrical stimulation lacks sufficient sensitivity to identify the language areas in children under age 10 years, often takes several hours to complete, and has a risk of stimulation-induced seizures. Thus, alternative language mapping techniques would be highly desirable in these children. We have recently developed a novel language mapping method which we refer to as "in-vivo animation of event-related gamma-oscillations". This new and innovative method appears promising for language mapping in children. As the next step, we will validate this mapping method using electrical stimulation and postoperative neuropsychological testing in this project. Specifically, we will determine whether brief auditory-language tasks will successively delineate gamma augmentation in the cortical sites responsible for receptive language function, expressive language function and overt speech. We will also determine whether a visual-language task will successively delineate gamma augmentation in the cortical sites responsible for receptive language function and expressive language function. Innovation in our project includes: (i) the study focusing on young subjects across a wide range of age (5 - 20 years), in about 40% of whom identification of the language cortex is difficult using electrical stimulation, (ii) in-vivo animation of cortical activation on an individual three-dimensional MRI with a good temporal resolution [10 msec] and a good spatial resolution [1 cm], and (iii) assessment of ECoG signals least affected by artifacts derived from overt speech tasks. This project is clinically significant since the results will be directly translatable into patient management and our event-related ECoG analysis has the potential to become a mainstream language mapping method which is less-invasive, more time-efficient, and more patient-friendly compared to the currently used electrical stimulation method.

Public Health Relevance

The goals of this research are (i) validation of the new mapping technique: "in-vivo animation of language- induced gamma oscillations on electrocorticography" as a new diagnostic tool for children who undergo brain surgeries and (ii) better understanding of the human language system. We will apply brief language tasks to children who undergo brain surgeries and identify the language-related brain areas, which are otherwise difficult to localize using the conventional electrical stimulation method. The results will introduce a novel, more time-efficient and patient-friendly language mapping method and are expected to improve the language outcome after brain surgeries in children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS064033-04
Application #
8233998
Study Section
Developmental Brain Disorders Study Section (DBD)
Program Officer
Fureman, Brandy E
Project Start
2009-03-01
Project End
2014-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
4
Fiscal Year
2012
Total Cost
$322,696
Indirect Cost
$105,192
Name
Wayne State University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Nishida, Masaaki; Zestos, Maria M; Asano, Eishi (2016) Spatial-temporal patterns of electrocorticographic spectral changes during midazolam sedation. Clin Neurophysiol 127:1223-32
Nonoda, Yutaka; Miyakoshi, Makoto; Ojeda, Alejandro et al. (2016) Interictal high-frequency oscillations generated by seizure onset and eloquent areas may be differentially coupled with different slow waves. Clin Neurophysiol 127:2489-99
Asano, Eishi; Gotman, Jean (2016) Is electrocorticography-based language mapping ready to replace stimulation? Neurology 86:1174-6
Kamson, David O; Pilli, Vinod K; Asano, Eishi et al. (2016) Cortical thickness asymmetries and surgical outcome in neocortical epilepsy. J Neurol Sci 368:97-103
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Matsuzaki, Naoyuki; Schwarzlose, Rebecca F; Nishida, Masaaki et al. (2015) Upright face-preferential high-gamma responses in lower-order visual areas: evidence from intracranial recordings in children. Neuroimage 109:249-59
Chugani, Harry T; Ilyas, Mohammed; Kumar, Ajay et al. (2015) Surgical treatment for refractory epileptic spasms: The Detroit series. Epilepsia 56:1941-9
Jeong, Jeong-Won; Asano, Eishi; Juhász, Csaba et al. (2015) Localization of specific language pathways using diffusion-weighted imaging tractography for presurgical planning of children with intractable epilepsy. Epilepsia 56:49-57
Toyoda, Goichiro; Brown, Erik C; Matsuzaki, Naoyuki et al. (2014) Electrocorticographic correlates of overt articulation of 44 English phonemes: intracranial recording in children with focal epilepsy. Clin Neurophysiol 125:1129-37

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