Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Other movement disorders that commonly mimic symptoms of PD include the Parkinsonian variant of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET). Taken together, these movement disorders affect over 10 million people in the United States alone. Current diagnostic approaches for PD, MSA, PSP, and ET are based on behavioral signs and clinical judgment, and this can often lead to the incorrect diagnosis, especially early in the course of the disease. In fact, it is estimated that 15% of patients in disease modifying drug trials for early PD do not have PD. Objective, valid, non- invasive, and biologically relevant markers of PD, MSA, PSP, and ET are pivotal for early and accurate diagnosis (trait), and for tracking disease progression (state). Our group has recently shown that diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) can be used to identify mechanisms for basal ganglia dysfunction in individuals with Parkinson's disease. Our preliminary data indicate that DTI and fMRI measures from the basal ganglia and cerebellum show excellent promise for differentiating PD, MSA, PSP, and ET, and for tracking longitudinal disease-specific changes in neurodegeneration. We will recruit 150 individuals for the study: 30 patients with PD, 30 patients with MSA, 30 patients with PSP, 30 patients with ET, and 30 control subjects.
In Aim 1, we will use DTI and fMRI of the basal ganglia and cerebellum to focus on the development of a sensitive and specific trait marker for each movement disorder.
In Aim 2, we will test the same individuals following 2 years using DTI and fMRI of the basal ganglia and cerebellum to develop state markers of neurodegeneration for each movement disorder. With the large and carefully diagnosed patient population at the Center for Movement Disorders and Neurorestoration and the state-of-the-art MRI facility at the McKnight Brain Institute, our group is uniquely positioned to complete the proposed study. The proposed research is innovative because it will utilize structural and functional imaging modalities with a 32-channel head coil performed on a state-of-the-art 3 Tesla MRI unit. The proposed research is significant because it will be the first stud to develop non-invasive trait and state markers of four debilitating movement disorders that affect over 10 million people in the United States.

Public Health Relevance

Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET) affect over 10 million people in the United States. These debilitating movement disorders can be very difficult to distinguish from each other, have different prognoses, and can respond very differently (if at all) to availabl therapies. The purpose of this grant is to identify structural and functional changes in the brain using non-invasive neuroimaging techniques to develop sensitive and specific markers for each of these diseases, and then to track how these markers change as each disease progresses to a 2 year time point.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS075012-03
Application #
8661314
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Babcock, Debra J
Project Start
2012-09-24
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$395,991
Indirect Cost
$131,997
Name
University of Florida
Department
Physiology
Type
Schools of Allied Health Profes
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Burciu, Roxana G; Seidler, Rachael D; Shukla, Priyank et al. (2018) Multimodal neuroimaging and behavioral assessment of ?-synuclein polymorphism rs356219 in older adults. Neurobiol Aging 66:32-39
Archer, Derek B; Coombes, Stephen A; Chu, Winston T et al. (2018) A widespread visually-sensitive functional network relates to symptoms in essential tremor. Brain 141:472-485
Burciu, Roxana G; Vaillancourt, David E (2018) Imaging of Motor Cortex Physiology in Parkinson's Disease. Mov Disord 33:1688-1699
Chung, Jae Woo; Burciu, Roxana G; Ofori, Edward et al. (2018) Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia. Neuroimage Clin 19:559-571
Lehericy, Stéphane; Vaillancourt, David E; Seppi, Klaus et al. (2017) The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward. Mov Disord 32:510-525
Chung, Jae Woo; Burciu, Roxana G; Ofori, Edward et al. (2017) Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication. Neuroimage Clin 14:417-421
Kang, Nyeonju; Christou, Evangelos A; Burciu, Roxana G et al. (2017) Sensory and motor cortex function contributes to symptom severity in spinocerebellar ataxia type 6. Brain Struct Funct 222:1039-1052
Ofori, Edward; Krismer, Florian; Burciu, Roxana G et al. (2017) Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study. Mov Disord 32:1457-1464
DeSimone, Jesse C; Pappas, Samuel S; Febo, Marcelo et al. (2017) Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia. Neurobiol Dis 106:124-132
Ofori, Edward; Du, Guangwei; Babcock, Debra et al. (2016) Parkinson's disease biomarkers program brain imaging repository. Neuroimage 124:1120-4

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