Cognitive and motor impairments are the two most common causes of disability in older adults. These two problems can lead to disabling forms of dementia and falls. Age-related cognitive and mobility impairments are clearly multifactorial, but with the rampant incidence of vascular disease in an aging population we cannot underestimate the role of cerebrovascular disease in age-related mobility disability and cognitive decline. Increasing evidence from epidemiological and clinico-pathological studies has established a strong link between vascular disease, particularly cerebral small vessel disease and the age- related clinical outcomes of cognitive and mobility impairment. However, our current research and knowledge is based on surrogate radiographic measure of small vessel disease which are mostly irreversible. The overall goal of this study is to identify vascular measures of cerebral small vessels which precede the onset of cognitive and motor decline and are predictive of clinical and radiographic outcomes in small vessel disease. Such measures would allow us to identify individuals in the pre-clinical state when our prevention and therapeutic interventions could have a higher impact. Moreover, these measures can also be used in future clinical trials to monitor disease progression and to evaluate new therapies.

Public Health Relevance

This study investigates cerebral vascular mechanisms leading to cognitive and mobility impairment in older adults. Cognitive and mobility impairments are a significant public health problem among elderly people. Cerebrovascular disease is a major contributor to these clinical outcomes. A better understanding of vascular mechanisms which precede cognitive and mobility impairment will advance our knowledge of this process and help us identify more effective preventions and treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS085002-01A1
Application #
8720312
Study Section
Aging Systems and Geriatrics Study Section (ASG)
Program Officer
Corriveau, Roderick A
Project Start
2014-06-01
Project End
2018-04-30
Budget Start
2014-06-01
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$418,259
Indirect Cost
$128,915
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Chow, Felicia C; Boscardin, W John; Mills, Claire et al. (2016) Cerebral vasoreactivity is impaired in treated, virally suppressed HIV-infected individuals. AIDS 30:45-55
Sorond, Farzaneh A; Cruz-Almeida, Yenisel; Clark, David J et al. (2015) Aging, the Central Nervous System, and Mobility in Older Adults: Neural Mechanisms of Mobility Impairment. J Gerontol A Biol Sci Med Sci 70:1526-32
Sorond, Farzaneh A; Tan, Can Ozan; LaRose, Sarah et al. (2015) Deferoxamine, Cerebrovascular Hemodynamics, and Vascular Aging: Potential Role for Hypoxia-Inducible Transcription Factor-1-Regulated Pathways. Stroke 46:2576-83
Pan, Wen-Chi; Eliot, Melissa N; Koutrakis, Petros et al. (2015) Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. PLoS One 10:e0134034
Tchalla, Achille E; Wellenius, Gregory A; Sorond, Farzaneh A et al. (2015) Elevated circulating vascular cell Adhesion Molecule-1 (sVCAM-1) is associated with concurrent depressive symptoms and cerebral white matter Hyperintensities in older adults. BMC Geriatr 15:62
Hajjar, Ihab; Sorond, Farzaneh; Lipsitz, Lewis A (2015) Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertension. J Am Geriatr Soc 63:276-81
Lipsitz, Lewis A; Habtemariam, Daniel; Gagnon, Margaret et al. (2015) Reexamining the Effect of Antihypertensive Medications on Falls in Old Age. Hypertension 66:183-9
Tchalla, Achille E; Wellenius, Gregory A; Travison, Thomas G et al. (2015) Circulating vascular cell adhesion molecule-1 is associated with cerebral blood flow dysregulation, mobility impairment, and falls in older adults. Hypertension 66:340-6