A number of the behavioral sequelae that occur after damage to the brain, such as stroke or traumatic injury, can be explained by abnormalities in the integration of sensory information and motor commands. This project uses brain imaging and non-invasive brain stimulation, combined with novel perturbations of grasping movements with robotics and virtual environments to study the roles played by frontoparietal brain areas in different stages of sensorimotor integration and to identify specific contributions of brain networks subserving goal-directed grasping. The overarching goal of this project is use a healthy-human lesion model to make causal inferences regarding the roles played by frontoparietal cortices in two major stages of sensorimotor integration: during motor planning when visual information of the target goal and haptic information of the hand is transformed into motor commands, and during movement updating when estimates of the sensory consequences of motor commands occur (generation of a forward model). We leverage the time-tested approaches involving perturbations to the target goal and the arm motor plant (perturbations of extrinsic and intrinsic space) that have been used to study sensorimotor integration in the reach system, and apply them to study the grasp circuit, which is controlled by a unique and segregated neural network that is comparatively understudied. This is the first systematic study in humans to test the unique contributions of frontoparietal cortices in planning and forward modeling of hand shape for grasping, and how these processes interact in the context of intrinsic versus extrinsic reference frames. The central goal of Aim 1 is to use functional magnetic resonance imaging (fMRI) to identify the neural bases of motor planning in external vs. internal space and accordingly test the causal involvement of these regions with fMRI-neuronavigated transient lesions elicited with transcranial magnetic stimulation.
Aim 2 complements the previous aim by testing the causal involvement of grasp-related frontoparietal areas in online updating of grasp. Here, we leverage multivariate analyses of kinematic responses to novel perturbations of hand configuration and movement goals during grasping to dissociate the involvement of these areas in generation of forward models for hand shape versus integrating sensory information into the motor plan.

Public Health Relevance

This project will advance our understanding of basic neural mechanisms of grasping, a largely understudied area of human neuroscience. It is highly relevant to public health because these findings will inform the neural underpinnings of sensorimotor integration, explain a host of pathologies of movement and perception, and aide in identifying cortical targets for interventions extracting neural signals for brain-computer interfaces and cortical stimulation in patient populations. PUBLIC HEALTH RELEVANCE: A number of brain disorders caused by cortical lesions due to stroke or trauma can be explained by abnormalities in integration of sensory information and motor commands. This project uses brain imaging and non-invasive brain stimulation, combined with novel perturbations of grasping movements with robotics and virtual environments to study the roles played by frontoparietal brain areas in different stages of sensorimotor integration and to identify specific contributions of brain networks subserving goal-directed grasping. This work will make important contributions in understanding the neural underpinnings of sensorimotor integration, a host of pathologies of movement and perception, and aide in identifying cortical targets for interventions. These findings will be relevant to the mission of the NIH, with broad interest to clinicians and basic scientists, and will have direct public health relevance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS085122-05
Application #
9210127
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Chen, Daofen
Project Start
2015-10-09
Project End
2017-12-31
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Northeastern University
Department
Other Health Professions
Type
Sch Allied Health Professions
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115