Although the most recognizable clinical feature of essential tremor (ET) is tremor, there is emerging evidence that non-motor features (esp. cognitive dysfunction) are present. A growing number of studies show that ET patients have poorer cognitive performance than age-matched controls. In some ET patients, the cognitive problems are severe. Also, recent epidemiological studies have demonstrated that ET patients are more likely to have mild cognitive impairment (MCI) than age-matched controls, and an increased risk of dementia. While ET appears to be a risk factor for the development of cognitive impairment, the cause is not currently known. The cerebellar basis for ET could contribute to cognitive impairment, yet there is other evidence that ET is associated with an increased risk of developing tau-related disorders (Alzheimer's disease [AD] and progressive supranuclear palsy [PSP]). This absence of a mechanistic understanding results in a difficult clinical predicament - there is presently no way to deduce whether a given ET patient, based on his/her observed cognitive features, has early AD, early PSP, or merely the expected cognitive profile of ET. We have no predictive guidelines for patients. What are the next steps? It is important to conclusively characterize the cognitive impairment of ET and to disentangle its component causes. The overall goal of the proposed research is to refine our understanding of this clinical-pathological entity.
We aim to perform longitudinal neuropsychological examinations on 350 ET cases and postmortem neuropathological examinations on 110 of these who die over 5 years, matching them to 220 autopsied non-ET cases. The novel concepts/new hypotheses we now put forward are as follows: i) for reasons that are as yet unclear, ET itself predisposes to tauopathic changes in the brain;thus, by extension, even if one were to match for level of cognitive impairment (normal cognition, MCI, or mild dementia), ET cases would still have more tau pathology than non-ET cases, ii) the nature/features of the tauopathy of ET is likely to differ from that of non-ET cases, iii) ET pathology alone, is likely to be the prime cause of cognitive deficits in a subgroup of ET cases, and iv) within the mix of ET cases, it should be possible to map certain cognitive profiles onto certain pathologies. Our 5-year proposal has two aims:
AIM 1 : To study the neuropathological basis of cognitive deficits in ET.
AIM 2 : To provide the first comprehensive characterization of cognition in ET and to demonstrate that the severity of certain cognitive deficits predicts non-ET pathology in ET. We expect that this research will elucidate the processes of dementia in ET and shape the counseling and treatment of ET patients with cognitive symptoms.

Public Health Relevance

Essential tremor (ET), among the most common neurological illnesses, has traditionally been regarded as a purely motor disorder, but there is a growing body of evidence that cognitive dysfunction is also present and, of additional import, that ET itself seems to be a risk factor for the development of dementia. This is an emerging and largely unexplored arena, and the goal of the proposed research is to lead the effort in determining the clinical and pathological characteristics of cognitive impairment associated with ET. We expect that the proposed research will elucidate the origins of and processes of cognitive impairment in ET and, in due course, have an effect on prognostic counseling and treatment of ET patients with emerging cognitive features.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
1R01NS086736-01A1
Application #
8758709
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Gwinn, Katrina
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Louis, Ravi J; Lee, Michelle; Kuo, Sheng-Han et al. (2014) Cellular density in the cerebellar molecular layer in essential tremor, spinocerebellar ataxia, and controls. Parkinsonism Relat Disord 20:1270-3
Louis, Elan D; Faust, Phyllis L (2014) Purkinje cell loss in essential tremor. Mov Disord 29:1329-30
Louis, Elan D (2014) Essential tremor: from bedside to bench and back to bedside. Curr Opin Neurol 27:461-7