Meningococcal disease (MD) is a serious public health problem, with high morbidity/mortality rates and case-fatality rate of approximately 10-20%. In 2007, the Brazilian National Immunization Program started to provide meningococcal C conjugate vaccine (MenC) for all HIV infected children, although there is no evidence that support this measure. It is neither proven that HIV infected children are in increased risk to MD, nor that MenC would be immunogenic in this population. The main aim of this proposal is to evaluate the immune response to MenC in HIV infected children. The sampling frame for this proposal is the approximately 180 persons enrolled at Instituto de Puericultura e Pediatria Martagao Gesteira, in Rio de Janeiro, Brazil. We will use a cohort design in our research targeting HIV infected children 2-13 years old who are assisted at the at IPPMG. These children during their regular appointment with their health care provider will be counseled to be immunized with MenC, and they will be invited to participate in this study. They will be immunized with 1 dose of the vaccine. Immune response of these children (serum bactericidal assay - SBA titers and Elisa) will be evaluated before the immunization, 30-60 days, and 12-18 months after the immunization. In this proposal we are going to study the short and long term response to the MenC, and comparing short term responders and non-responders to the vaccine, to assess possible factors associated with the response.

Public Health Relevance

Meningococcal disease (MD) is a serious public health problem, with high morbidity/mortality rates. The main aim of this project is to evaluate the immune response of meningococcal C conjugate vaccine in a group of HIV infected children.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project (R01)
Project #
5R01TW008397-04
Application #
8321375
Study Section
Special Emphasis Panel (ZRG1-BDA-K (50))
Program Officer
Liu, Xingzhu
Project Start
2009-09-01
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$50,252
Indirect Cost
$3,722
Name
Federal University of Rio de Janeiro
Department
Type
DUNS #
900848466
City
Rio de Janeiro
State
Country
Brazil
Zip Code
21941-901
Milagres, Lucimar G; Costa, Priscilla R; Santos, Bianca A N et al. (2013) CD4+ T-cell activation impairs serogroup C Neisseria meningitis vaccine response in HIV-infected children. AIDS 27:2697-705