In northern Tanzania, febrile disease caused by the zoonotic pathogens, Leptospira, Coxiella and Brucella spp., account for 11 times more febrile admissions than malaria. These pathogens can infect and be transmitted among a wide range of host species. However, almost nothing is known about transmission patterns among animal hosts, which host species are responsible for transmission to humans, or the key social, economic and behavioral determinants of human disease risk in different agro-ecological settings. This project will integrate several disciplinary approaches, including social behavioral studies, human febrile illness surveillance, and linked human-animal epidemiological studies, to generate data for incorporation into models of human disease risk. These models, together with an understanding of community risk perception and knowledge, will allow us to identify appropriate strategies for disease control and prevention. Intellectual merit: This joint UK-US proposal will be the first integrated study of the impact and social ecology of bacterial zoonoses in Africa. This project brings together medical, veterinary, ecology, and social science research groups that have independently become well-established in Tanzania, but are now working together for the first time. These partnerships provide a unique blend of expertise necessary to conduct the inter-disciplinary research needed to address gaps in knowledge addressing the wide-ranging questions related to zoonoses infection dynamics and disease control. The study will incorporate an interactive methodology with social science approaches both feeding into epidemiological studies as well as building on the outputs from analyses of potential intervention strategies. Broader implications: The scope of the study allows us to investigate disease ecology over a wide range of agro-ecological settings broadly typical of much of rural and peri-urban Africa. Across Africa, increasing attention needs to be given to zoonotic causes of non-differentiated human febrile illness.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project (R01)
Project #
5R01TW009237-03
Application #
8484900
Study Section
Special Emphasis Panel (ZRG1-BDCN-T (80))
Program Officer
Jessup, Christine
Project Start
2011-09-01
Project End
2015-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$425,544
Indirect Cost
$56,419
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Ghai, Ria R; Thurber, Mary I; El Bakry, Azza et al. (2016) Multi-method assessment of patients with febrile illness reveals over-diagnosis of malaria in rural Uganda. Malar J 15:460
Im, Justin; Nichols, Chelsea; Bjerregaard-Andersen, Morten et al. (2016) Prevalence of Salmonella Excretion in Stool: A Community Survey in 2 Sites, Guinea-Bissau and Senegal. Clin Infect Dis 62 Suppl 1:S50-5
von Kalckreuth, Vera; Konings, Frank; Aaby, Peter et al. (2016) The Typhoid Fever Surveillance in Africa Program (TSAP): Clinical, Diagnostic, and Epidemiological Methodologies. Clin Infect Dis 62 Suppl 1:S9-S16
Zhang, Helen L; Mnzava, Kunda W; Mitchell, Sarah T et al. (2016) Mixed Methods Survey of Zoonotic Disease Awareness and Practice among Animal and Human Healthcare Providers in Moshi, Tanzania. PLoS Negl Trop Dis 10:e0004476
Bennett, Andrew J; Sibley, Samuel D; Lauck, Michael et al. (2016) Naturally Circulating Hepatitis A Virus in Olive Baboons, Uganda. Emerg Infect Dis 22:1308-10
Wahl-Jensen, Victoria; Johnson, Joshua C; Lauck, Michael et al. (2016) Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques. MBio 7:e02009-15
Panzner, Ursula; Pak, Gi Deok; Aaby, Peter et al. (2016) Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program. Clin Infect Dis 62 Suppl 1:S56-68
Kuhn, Jens H; Lauck, Michael; Bailey, Adam L et al. (2016) Reorganization and expansion of the nidoviral family Arteriviridae. Arch Virol 161:755-68
Wong, Vanessa K; Baker, Stephen; Connor, Thomas R et al. (2016) An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid. Nat Commun 7:12827
Park, Se Eun; Pak, Gi Deok; Aaby, Peter et al. (2016) The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa. Clin Infect Dis 62 Suppl 1:S23-31

Showing the most recent 10 out of 88 publications