In northern Tanzania, febrile disease caused by the zoonotic pathogens, Leptospira, Coxiella and Brucella spp., account for 11 times more febrile admissions than malaria. These pathogens can infect and be transmitted among a wide range of host species. However, almost nothing is known about transmission patterns among animal hosts, which host species are responsible for transmission to humans, or the key social, economic and behavioral determinants of human disease risk in different agro-ecological settings. This project will integrate several disciplinary approaches, including social behavioral studies, human febrile illness surveillance, and linked human-animal epidemiological studies, to generate data for incorporation into models of human disease risk. These models, together with an understanding of community risk perception and knowledge, will allow us to identify appropriate strategies for disease control and prevention. Intellectual merit: This joint UK-US proposal will be the first integrated study of the impact and social ecology of bacterial zoonoses in Africa. This project brings together medical, veterinary, ecology, and social science research groups that have independently become well-established in Tanzania, but are now working together for the first time. These partnerships provide a unique blend of expertise necessary to conduct the inter-disciplinary research needed to address gaps in knowledge addressing the wide-ranging questions related to zoonoses infection dynamics and disease control. The study will incorporate an interactive methodology with social science approaches both feeding into epidemiological studies as well as building on the outputs from analyses of potential intervention strategies. Broader implications: The scope of the study allows us to investigate disease ecology over a wide range of agro-ecological settings broadly typical of much of rural and peri-urban Africa. Across Africa, increasing attention needs to be given to zoonotic causes of non-differentiated human febrile illness.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project (R01)
Project #
5R01TW009237-03
Application #
8484900
Study Section
Special Emphasis Panel (ZRG1-BDCN-T (80))
Program Officer
Jessup, Christine
Project Start
2011-09-01
Project End
2015-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$425,544
Indirect Cost
$56,419
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Cash-Goldwasser, Shama; Maze, Michael J; Rubach, Matthew P et al. (2018) Risk Factors for Human Brucellosis in Northern Tanzania. Am J Trop Med Hyg 98:598-606
Scully, Erik J; Basnet, Sarmi; Wrangham, Richard W et al. (2018) Lethal Respiratory Disease Associated with Human RhinovirusĀ C in Wild Chimpanzees, Uganda, 2013. Emerg Infect Dis 24:267-274
Maze, M J; Bassat, Q; Feasey, N A et al. (2018) The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management. Clin Microbiol Infect 24:808-814
Carugati, Manuela; Biggs, Holly M; Maze, Michael J et al. (2018) Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007-2008 and 2012-2014. Trans R Soc Trop Med Hyg 112:136-143
Buechler, Connor R; Bailey, Adam L; Lauck, Michael et al. (2017) Genome Sequence of a Novel Kunsagivirus (Picornaviridae: Kunsagivirus) from a Wild Baboon (Papio cynocephalus). Genome Announc 5:
Goldberg, Tony L; Bennett, Andrew J; Kityo, Robert et al. (2017) Kanyawara Virus: A Novel Rhabdovirus Infecting Newly Discovered Nycteribiid Bat Flies Infesting Previously Unknown Pteropodid Bats in Uganda. Sci Rep 7:5287
Marks, Florian; von Kalckreuth, Vera; Aaby, Peter et al. (2017) Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study. Lancet Glob Health 5:e310-e323
Weny, Geoffrey; Okwee-Acai, James; Okech, Samuel George et al. (2017) Prevalence and Risk Factors Associated with Hemoparasites in Cattle and Goats at the Edge of Kibale National Park, Western Uganda. J Parasitol 103:69-74
Simons, Noah D; Eick, Geeta N; Ruiz-Lopez, Maria J et al. (2017) Cis-regulatory evolution in a wild primate: Infection-associated genetic variation drives differential expression of MHC-DQA1 inĀ vitro. Mol Ecol 26:4523-4535
Moncla, Louise H; Weiler, Andrea M; Barry, Gabrielle et al. (2017) Within-Host Evolution of Simian Arteriviruses in Crab-Eating Macaques. J Virol 91:

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