Aging is often accompanied by weight loss and changes in body composition. Evidence is growing that central obesity increases the risk of cognitive decline and dementia. The pathways by which this occurs are not well understood. Systolic and diastolic blood pressure, which are generally influenced by obesity and overweight, often follow nonlinear trajectories in old age. Little is known about the effects of co-occurring changes in body composition and blood pressures on cognitive/functional decline. This proposal will examine the effects of obesity, central body adiposity, body composition and blood pressure on cognitive and functional decline in the Sacramento Area Latino Study of Aging, a cohort of older Mexican Americans (n=1789) that was followed at six and 12 month intervals from 1998-2008. This application focuses on analysis of existing data and will take advantage of a rich, longitudinal dataset to address the influence of trajectories of modifiable risk factors on cognitive and functional decline and mortality over seven years of follow-up in a high risk elderly cohort. Body composition and blood pressure are interrelated risk factors that exhibit age-related changes over time. Clearly, obesity is associated with higher blood pressure which has been linked to subsequent cognition and functional decline. Declines in physical performance and physical activity also play a role in trajectories of change in blood pressure and body composition. Age-related changes in body composition are characterized by increases in body fat and decreases in lean muscle mass, along with weight loss. Whether these changes in body composition are followed by changes in blood pressure in older people is not well studied. Further, the role in this association of inflammatory and hormonal factors such as C-reactive protein, IL-6 and receptors, TNF-alpha and receptors, leptin, or adiponectin is not delineated.
The aims of this analysis project are shown below.
AIM 1. Evaluate the effects of change in systolic and diastolic blood pressure, hypertension treatment, and peripheral vascular disease on cognitive and functional decline AIM 2. Evaluate the effects of several measures of weight/body composition and trajectories of change in weight/body composition on cognitive and functional decline.
AIM3. Evaluate the effects of age-related changes in weight/body composition on trajectories of change in 5 different blood pressure measures and their association with cognitive and functional decline.
AIM 4. Evaluate metabolic, inflammatory and hormonal mediators of the associations between blood pressure and anthropometric factors and cognitive and functional decline.

Public Health Relevance

This study will examine the effects of hypertension and body composition on cognitive and functional decline in older Mexican Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Research Grants (R03)
Project #
5R03AG033751-02
Application #
8111806
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Anderson, Dallas
Project Start
2010-07-15
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2011
Total Cost
$60,887
Indirect Cost
Name
University of California San Francisco
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Garcia, Maria E; Lee, Anne; Neuhaus, John et al. (2016) Diabetes Mellitus as a Risk Factor for Development of Depressive Symptoms in a Population-Based Cohort of Older Mexican Americans. J Am Geriatr Soc 64:619-24
Haan, Mary N; Lee, Anne; Odden, Michelle C et al. (2016) Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans. J Gerontol A Biol Sci Med Sci 71:1089-95
Garcia, Lorena; Lee, Anne; Zeki Al Hazzouri, Adina et al. (2015) The Impact of Neighborhood Socioeconomic Position on Prevalence of Diabetes and Prediabetes in Older Latinos: The Sacramento Area Latino Study on Aging. Hisp Health Care Int 13:77-85
Mayeda, Elizabeth R; Haan, Mary N; Yaffe, Kristine et al. (2015) Does type 2 diabetes increase rate of cognitive decline in older Mexican Americans? Alzheimer Dis Assoc Disord 29:206-12
Zeki Al Hazzouri, Adina; Haan, Mary N; Deng, Yingzi et al. (2014) Reduced heart rate variability is associated with worse cognitive performance in elderly Mexican Americans. Hypertension 63:181-7
López, Lenny; Peralta, Carmen A; Lee, Anne et al. (2014) Impact of acculturation on cardiovascular risk factors among elderly Mexican Americans. Ann Epidemiol 24:714-9
Mayeda, Elizabeth R; Haan, Mary N; Kanaya, Alka M et al. (2013) Type 2 diabetes and 10-year risk of dementia and cognitive impairment among older Mexican Americans. Diabetes Care 36:2600-6
Levine, Deborah A; Haan, Mary N; Langa, Kenneth M et al. (2013) Impact of gender and blood pressure on poststroke cognitive decline among older Latinos. J Stroke Cerebrovasc Dis 22:1038-45
Zeki Al Hazzouri, Adina; Haan, Mary N; Neuhaus, John M et al. (2013) Cardiovascular risk score, cognitive decline, and dementia in older Mexican Americans: the role of sex and education. J Am Heart Assoc 2:e004978

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