The aim of this project is to examine age-specific changes in biomarkers and age-specific onset of physiological dysregulation across a range of countries with varying epidemiological, economic, behavioral and cultural conditions. We will also link demographic, social, and behavioral factors to the onset of risk across countries including the U.S., England, Taiwan, Mexico, and Indonesia. The data used in this project include the following nationally representative samples that have been harmonized as appropriate for cross-country comparisons: the Health and Retirement Study (HRS) for 2006 and 2010, the English Longitudinal Study of Ageing (ELSA) for 2004 and 2008, the Social Environment and Biomarkers of Aging Study (SEBAS) for 2000 and 2006, the Mexican Family Life Survey (MxFLS) for 2002, 2006, and 2009, and the Indonesia Family Life Survey (IFLS) for 2000 and 2007-8. Recent collection of multiple waves of biomarker data in many areas of the world provides an unparalleled opportunity to systematically and comprehensively study age-specific onset of physiological change, as well as prevalence of risk for a variety of health outcomes, at the national level in countries with varying health histories, health behaviors, and social, cultural and health system characteristics.

Public Health Relevance

It is important to understand age-specific changes in biomarkers and prevalence and age-specific onset of physiological dysregulation across a range of countries with varying epidemiological, economic, behavioral and cultural conditions. Findings from cross-country comparisons will not only provide better understanding of health differences across countries, they will also contribute to understanding the process of biological aging in different circumstances. In addition, clarifying differential links between demographic, social, and behavioral factors with the biological risk will provide better understanding on how to improve physiological status in different populations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Research Grants (R03)
Project #
5R03AG040609-02
Application #
8323229
Study Section
Special Emphasis Panel (ZRG1-PSE-H (80))
Program Officer
Haaga, John G
Project Start
2011-09-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$67,240
Indirect Cost
$26,240
Name
University of Southern California
Department
None
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089