In this proposal, we will investigate the computations for cue combination underlying auditory spatial sensitivity in the nucleus of the brachium of the inferior colliculus (BIN). We will characterize the receptive fields for both location and frequenc by presenting sound stimuli while simultaneously recording extracellular responses from neurons in the BIN. In addition, we will characterize and model multi-cue interaction underlying these receptive fields by measuring responses to sound stimuli with random spectral shapes. The results of this study will elucidate the neural mechanisms underlying the integration of sound localization cues necessary for the formation of objects in the ascending auditory system. An unsolved problem in auditory neural prostheses is producing an adequate sense of the spatial location of stimuli. This information is important for spatial unmasking in multi-talker environments as well as for localizing sounds. An understanding of how auditory spatial fields are constructed in the BIN should be useful in determining which sound localization cues need to be provided and in what form. Finally, the results of this work are also a prerequisite for planning an experimental investigation of the deficits in the sound localization representation in hearing impairment.

Public Health Relevance

An unsolved problem in auditory neural prostheses is producing an adequate sense of the spatial location of stimuli. This information is important for speech comprehension in multi-talker environments as well as for localizing sounds. An understanding of how auditory spatial fields are constructed in the brain will determine which sound localization cues need to be provided and in what form.

Agency
National Institute of Health (NIH)
Type
Small Research Grants (R03)
Project #
5R03DC012124-03
Application #
8706844
Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Platt, Christopher
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
None
Type
Organized Research Units
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239