Abstract

This is a proposal to test the hypothesis that the ornithine decarboxylase-antizyme gene (ODC-Az) is a tumor suppressor gene in oral cancer Under Aim 1 the tumor suppressing-potential will be evaluated in malignant hamster oral keratinocytes by introducing the gene in an inducible retrovirus system.
Under Aim 2 the regulatory region of the gene will be examined in orde to find if loss of expression is due to changes in that region.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Research Grants (R03)
Project #
5R03DE012529-02
Application #
2856666
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1998-01-01
Project End
1999-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Dentistry
Type
Schools of Dentistry
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115