A century after theories identified the prominent roles of sugars in dental caries etiology and the discovery of the beneficial effects of fluorides, caries remains a highly prevalent disease throughout childhood, including adolescence. Adolescents'greater independence and frequent exposure to sugared beverages (e.g., soda pop) appear to place them at greater risk than at younger ages. However, these caries incidence patterns and relationships with risk factors are poorly understood because there are few studies of caries incidence or risk factors among adolescent subjects. Since 1991, using a cohort recruited at birth, the ongoing Iowa Fluoride Study (IFS) has comprehensively assessed the relationships between dietary data and fluoride exposures and dental caries in individuals at ages 5, 9, and 13. As caries continues to be a significant disease in adolescents, the proposed study provides a unique opportunity to assess the effects of socio-demographic, dietary, fluoride, and other factors on the incidence of dental caries during adolescence from age 13 to 17 years in our cohort. The main objectives of this proposal are to 1) conduct detailed secondary analyses of patterns of dental caries of the permanent dentition at age 17 and caries incidence from 13 to 17, and 2) comprehensively examine the relationships among dental caries incidence from age 13 to 17 (and age 17 prevalence) and dietary, fluoride, prior caries experience, and socio-demographic factors. Multivariable analyses will assess the relationships between and interactions among caries outcomes (incidence/increments and prevalence/counts) and longitudinally-collected data on various dietary patterns, oral health behaviors, fluoride exposures, previous caries experience, socio-demographics, and other factors. We will then assess the consistency of our findings concerning caries risk factors for ages 13 to 17 with those from analyses of caries risk factors during earlier periods from ages 5 to 9 and 9 to 13. As studies involving recruitment and successful retention of a cohort from birth are extremely rare, the Iowa Fluoride Study offers a unique opportunity to study these relationships in unprecedented detail, enhancing our ability to develop effective adolescent caries prevention programs.

Public Health Relevance

to Public Health Dental caries (tooth decay) remains the most common disease of childhood and adolescence despite more than 65 years of using fluoride to prevent cavities, and little is known about tooth decay during adolescence. Secondary data analysis of data currently being collected for the Iowa Fluoride Study cohort at age 17 provides a unique opportunity to better understand adolescent caries and the effects of demographic and dietary factors, fluoride exposures, previous caries experience, and other factors. Findings will improve our understanding of the disease and help to develop better strategies to prevent dental caries during adolescence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Research Grants (R03)
Project #
1R03DE023784-01
Application #
8612838
Study Section
Special Emphasis Panel (ZDE1-JR (17))
Program Officer
Fischer, Dena
Project Start
2014-08-10
Project End
2016-07-31
Budget Start
2014-08-10
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$151,000
Indirect Cost
$51,000
Name
University of Iowa
Department
Dentistry
Type
Schools of Dentistry
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264
Warren, John J; Van Buren, John M; Levy, Steven M et al. (2017) Dental caries clusters among adolescents. Community Dent Oral Epidemiol 45:538-544
Marshall, Teresa A; Van Buren, John M; Warren, John J et al. (2017) Beverage Consumption Patterns at Age 13 to 17 Years Are Associated with Weight, Height, and Body Mass Index at Age 17 Years. J Acad Nutr Diet 117:698-706
VanBuren, John; Cavanaugh, Joseph; Marshall, Teresa et al. (2017) AIC identifies optimal representation of longitudinal dietary variables. J Public Health Dent 77:360-371