Among the limited supply of organs available for liver transplantation, a wide spectrum of quality exists. Some organs carry higher risks of disease transmission, and others carry higher risks of graft failure ranging from 20% to 40% at 3 years. Each time an organ offer is made, the patient and physician must decide whether to accept this offer, or wait for a better one to come along. Our prior research has demonstrated that these decisions vary widely by transplant center, are inconsistent with the available evidence, and are susceptible to cognitive biases and external forces such as policy changes and competition between centers. This research proposes to improve organ acceptance decisions, as follows. 1) Using data from the Scientific Registry of Transplant Recipients, we will develop and validate a statistical model to predict whether a given patient would be better off accepting a given offer, versus waiting for a better one to come along. 2) Next, we will use this statistical model to creat and pilot test a point-of-care physician decision aid. This tool will be designed for use on a computer, tablet, or smart phone, and will be intended to guide physicians in deciding whether to accept an organ offer on behalf of a patient.

Public Health Relevance

The overarching goal of this proposal is to improve decision making about organ quality in liver transplantation, specifically by creating a decision aid for physicians that is tailored to the individual patient and donor organ. This work will use technology to bring data to the point of care, thus facilitating clinical decisions which will resut in prolonged survival and improved health among patients with liver disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Research Grants (R03)
Project #
1R03DK097369-01
Application #
8426739
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2013-05-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
1
Fiscal Year
2013
Total Cost
$76,467
Indirect Cost
$15,820
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109