Our laboratory has recently identified a spontaneous mouse mutant with an ocular phenotype that we will refer to as Big Eyes (BE). Histological analysis of the BE mice indicated an enlarged anterior chamber that correlated with the appearance of an epithelialization of the corneal endothelium and proliferation of these epithelial cells into the iridocorneal angle. It is our hypothesis that blockage of the iridocorneal angle in BE mice produces an increase in intraocular pressure and that this mouse is a model for human diseases such as posterior polymorphous dystrophy (PPD) or iridocorneal endothelial syndrome (ICE) and associated conditions including glaucoma. The preliminary genetics of the BE phenotype suggest a single gene displaying autosomal dominance and numerous genetic modifiers within the mouse genome. The objectives of this proposal are to characterize the clinical and pathological features of the BE phenotype and to identify its underlying genetic causes using a gene mapping approach. ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Research Grants (R03)
Project #
1R03EY015565-01A1
Application #
6878359
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Liberman, Ellen S
Project Start
2004-12-02
Project End
2007-11-30
Budget Start
2004-12-02
Budget End
2005-11-30
Support Year
1
Fiscal Year
2005
Total Cost
$145,500
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715