Malaria is one of the gravest threats to the health of pregnant women and their unborn babies. Malaria in pregnancy (MIP) is associated with an increased risk of fetal death, prematurity, intrauterine growth retardation (IUGR), low birth weight (LBW), and maternal anemia. In recent years, malaria has reemerged as a public health problem in India, with 1.5-2 million documented cases reported annually by India's National Malaria Control Programme, though these figures probably substantially underestimate the true burden of disease. The development and implementation of effective policies for the prevention and control of MIP in India has been hampered by a lack of detailed information on malaria-associated morbidity during pregnancy and the impact of malaria on birth outcomes. To address these issues, we are proposing a study to be conducted in two districts of Chhattisgarh state, India, one with stable malaria transmission and one with unstable transmission.
We aim to establish the impact of MIP on maternal anemia, birth outcomes (LBW, IUGR, and stillbirths), and the relative contributions of Plasmodium falciparum and P. vivaxto malaria-associated morbidity. In addition, we will assess the current availability of MIP interventions, such as chloroquine prophylaxis and insecticide treated bednets, and patient/clinic level factors that influence the utilization of such interventions. This project will be a collaborative effort between scientists at Boston University's Center for International Health and Development, the National Malaria Research Center in Jabalbur, India, and the Malaria Branch of the Centers for Disease Control and Prevention in Atlanta. This project will serve to strenghten the collaborative relationship of these institutions while enhancing the capacity of Indian researchers to design, implement, and analyze data from applied research studies. The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD052167-02
Application #
7289309
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Reddy, Uma M
Project Start
2006-09-20
Project End
2009-08-31
Budget Start
2007-09-01
Budget End
2009-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$78,894
Indirect Cost
Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Wylie, Blair J; Singh, Mrigendra P; Coull, Brent A et al. (2015) Association between wood cooking fuel and maternal hypertension at delivery in central East India. Hypertens Pregnancy 34:355-68
Singh, Neeru; Bharti, Praveen K; Singh, Mrigendra P et al. (2015) What is the burden of submicroscopic malaria in pregnancy in central India? Pathog Glob Health 109:30-8
Wylie, Blair J; Coull, Brent A; Hamer, Davidson H et al. (2014) Impact of biomass fuels on pregnancy outcomes in central East India. Environ Health 13:1
Jaakkola, Kari; Saukkoriipi, Annika; Jokelainen, Jari et al. (2014) Decline in temperature and humidity increases the occurrence of influenza in cold climate. Environ Health 13:22
Singh, Neeru; Singh, Mrigendra P; Wylie, Blair J et al. (2012) Malaria prevalence among pregnant women in two districts with differing endemicity in Chhattisgarh, India. Malar J 11:274
Wylie, Blair J; Hashmi, Ahmar H; Singh, Neeru et al. (2010) Availability and utilization of malaria prevention strategies in pregnancy in eastern India. BMC Public Health 10:557