Superstorm Sandy's effects on New York University Langone Medical Center (NYULMC): On October 29th, 2012, NYULMC experienced an unprecedented storm. A massive Hurricane with extremely high winds and a 14.2 foot storm surge struck New York City at high tide and flooded many areas of New York City, including NYULMC, which lies immediately adjacent to the East River (Figs. 1 &2). The flooding at NYULMC caused damage that deeply impacted patient care, research, and educational facilities. NYULMCs emergency power system was designed and built according to all safety codes to withstand a surge higher than the highest flood level for New York City in the past century. Superstorm Sandy obviously exceeded those levels. The main campus of NYULMC incurred extensive damage to its mechanical, electrical, and plumbing systems, requiring its temporary closure.
Due to evolution; jak and stat genes exist in very similar forms in other organisms; such as the fruit fly Drosophila. The fruit fly is an excellent genetic organis that has been used for many years in research laboratories and with great success to identify and characterize genes critical for basic biological processes. Our study is designed to eludicate how the JAK/STAT pathway regulates cell competition in Drosophila.
|Amoyel, Marc; Anderson, Abigail M; Bach, Erika A (2014) JAK/STAT pathway dysregulation in tumors: a Drosophila perspective. Semin Cell Dev Biol 28:96-103|
|Amoyel, Marc; Simons, Benjamin D; Bach, Erika A (2014) Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J 33:2295-313|
|Amoyel, Marc; Bach, Erika A (2014) Cell competition: how to eliminate your neighbours. Development 141:988-1000|
|Amoyel, Marc; Sanny, Justina; Burel, Michael et al. (2013) Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Development 140:56-65|
|Rodrigues, Aloma B; Zoranovic, Tamara; Ayala-Camargo, Aidee et al. (2012) Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development 139:4051-61|