Intracranial aneurysms carry a risk of rupture with potentially life-threatening subarachnoid hemorrhage. Study of the hemodynamic properties of cerebral vasculature in patients with ruptured and unruptured intracranial aneurysms could provide insight into the factors that influence why some aneurysms rupture and others do not. Blood flow velocity within cerebral blood vessels, an important hemodynamic property in aneurysmal disease, is usually measured by probes placed on the skin, or estimated by computer modeling software. However, these methods are prone to error. We propose the measurement of both blood flow velocity and blood pressure from within precise blood vessel locations using Doppler flow wire technology during cerebral angiography for aneurysm treatment. These measurements can be applied to real-time calculations of the hemodynamic forces on intracranial aneurysms, as well as improve the accuracy of computer-based aneurysm hemodynamics modeling. The study of such measurements in aneurysm patients will provide further insight into aneurysmal disease, as well as a pathophysiological basis for treatment decisions.

Public Health Relevance

The proposed study will use Doppler flow wire technology to measure blood flow velocity and blood pressure from within cerebral blood vessels harboring intracranial aneurysms. These measurements can be used to calculate forces of hemodynamic stress in real-time, and improve the accuracy of computational models of aneurysm systems. This novel translational approach provides real-time information to aid in risk stratification and management of ruptured and unruptured intracranial aneurysms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Research Grants (R03)
Project #
1R03NS078539-01
Application #
8281303
Study Section
Special Emphasis Panel (ZRG1-NT-L (09))
Program Officer
Koenig, James I
Project Start
2012-02-15
Project End
2014-01-31
Budget Start
2012-02-15
Budget End
2013-01-31
Support Year
1
Fiscal Year
2012
Total Cost
$77,146
Indirect Cost
$27,146
Name
University of Washington
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
McGah, Patrick M; Levitt, Michael R; Barbour, Michael C et al. (2014) Accuracy of computational cerebral aneurysm hemodynamics using patient-specific endovascular measurements. Ann Biomed Eng 42:503-14
Levitt, M R; McGah, P M; Aliseda, A et al. (2014) Cerebral aneurysms treated with flow-diverting stents: computational models with intravascular blood flow measurements. AJNR Am J Neuroradiol 35:143-8