Intracranial aneurysms carry a risk of rupture with potentially life-threatening subarachnoid hemorrhage. Study of the hemodynamic properties of cerebral vasculature in patients with ruptured and unruptured intracranial aneurysms could provide insight into the factors that influence why some aneurysms rupture and others do not. Blood flow velocity within cerebral blood vessels, an important hemodynamic property in aneurysmal disease, is usually measured by probes placed on the skin, or estimated by computer modeling software. However, these methods are prone to error. We propose the measurement of both blood flow velocity and blood pressure from within precise blood vessel locations using Doppler flow wire technology during cerebral angiography for aneurysm treatment. These measurements can be applied to real-time calculations of the hemodynamic forces on intracranial aneurysms, as well as improve the accuracy of computer-based aneurysm hemodynamics modeling. The study of such measurements in aneurysm patients will provide further insight into aneurysmal disease, as well as a pathophysiological basis for treatment decisions.
The proposed study will use Doppler flow wire technology to measure blood flow velocity and blood pressure from within cerebral blood vessels harboring intracranial aneurysms. These measurements can be used to calculate forces of hemodynamic stress in real-time, and improve the accuracy of computational models of aneurysm systems. This novel translational approach provides real-time information to aid in risk stratification and management of ruptured and unruptured intracranial aneurysms.
|Levitt, Michael R; Barbour, Michael C; Rolland du Roscoat, Sabine et al. (2017) Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach. J Neurointerv Surg 9:0|
|Barbour, Michael C; McGah, Patrick M; Ng, Chin H et al. (2015) Convective Leakage Makes Heparin Locking of Central Venous Catheters Ineffective Within Seconds: Experimental Measurements in a Model Superior Vena Cava. ASAIO J 61:701-9|
|McGah, P M; Nerva, J D; Morton, R P et al. (2015) In vitro validation of endovascular Doppler-derived flow rates in models of the cerebral circulation. Physiol Meas 36:2301-17|
|McGah, Patrick M; Levitt, Michael R; Barbour, Michael C et al. (2014) Accuracy of computational cerebral aneurysm hemodynamics using patient-specific endovascular measurements. Ann Biomed Eng 42:503-14|
|Levitt, M R; McGah, P M; Aliseda, A et al. (2014) Cerebral aneurysms treated with flow-diverting stents: computational models with intravascular blood flow measurements. AJNR Am J Neuroradiol 35:143-8|