Abstract

Repeat proteins are found in all three phyla and present in some 6% of all eukaryotic protein coding sequences [1]. They are made up of tandem arrays of similar amino acid stretches that fold up into elongated architectures of repeating structural motifs that stack one upon the next producing extended superhelical structures [2]. Repeat proteins, by virtue of their inherent symmetries both in primary sequence and three dimensional structure, stand as remarkable models where the sequence-codes-folding-codes-function

Public Health Relevance

Transcription factors are proteins that control the synthesis of mRNA from genomes. Among transcription factors, the NF-:B transcription factor family, is found misregulated in diseases such as cancer, arthritis, asthma, diabetes, AIDS and viral infections [6]. This family is regulated by inhibitors called I:Bs and we have shown that I:B1;folds

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
5R03TW008232-03
Application #
8056064
Study Section
International and Cooperative Projects - 1 Study Section (ICP1)
Program Officer
Sina, Barbara J
Project Start
2009-04-15
Project End
2012-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
3
Fiscal Year
2011
Total Cost
$33,655
Indirect Cost

  Institution

Name
University of California San Diego
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Jenik, Michael; Parra, R Gonzalo; Radusky, Leandro G et al. (2012) Protein frustratometer: a tool to localize energetic frustration in protein molecules. Nucleic Acids Res 40:W348-51
Ferreiro, Diego U; Hegler, Joseph A; Komives, Elizabeth A et al. (2011) On the role of frustration in the energy landscapes of allosteric proteins. Proc Natl Acad Sci U S A 108:3499-503
DeVries, Ingrid; Ferreiro, Diego U; Sánchez, Ignacio E et al. (2011) Folding kinetics of the cooperatively folded subdomain of the I?B? ankyrin repeat domain. J Mol Biol 408:163-76
Ferreiro, Diego U; Komives, Elizabeth A (2010) Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha. Biochemistry 49:1560-7