Liver disease is a major contributor to morbidity/mortality among those with HIV. The etiologies of liver disease include hepatitis C virus (HCV) and hepatitis B virus (HBV) infection as well as drug-induced liver toxicity. Direct effects of HIV on stellate cell activation, and on alteration of the cytokine milieu in the liver contribute to injury. Research and information sharing remain fragmented along specialty lines. In an ongoing effort to improve communication, stimulate the research agenda, and develop new productive collaborations, we propose the continuation of a series of national/international conferences on HIV and liver disease. The proposed conferences will take place over a three day period in 2012, and 2014 which will bring together leading experts in the field. In addition, young investigators and trainees will be encouraged to attend via a scholarship mechanism supported by this grant. Meeting outcomes include provision of continuing medical education credit, development of a published manuscript on the subject, and the availability of a web-based educational site. Particular attention will be paid to development of new research concepts and establishment of collaborative associations by participants.

Public Health Relevance

Liver disease has become an important problem among people infected with the human immunodeficiency virus (HIV). This proposal describes continuation of a national/international forum bringing together U.S. and international experts in the field to review the most current information and to develop research strategies that will reduce the health impact of liver disease in these patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Conference (R13)
Project #
2R13AI071925-05
Application #
8326893
Study Section
Special Emphasis Panel (ZAI1-MFH-M (J1))
Program Officer
Gutierrez, Martin
Project Start
2006-07-01
Project End
2015-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$40,000
Indirect Cost
Name
University of Cincinnati
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Sherman, Kenneth E; Thomas, David; Chung, Raymond T (2014) Human immunodeficiency virus and liver disease forum 2012. Hepatology 59:307-17
Sherman, Kenneth E; Thomas, David L; Chung, Raymond T (2011) Human immunodeficiency virus and liver disease forum 2010: conference proceedings. Hepatology 54:2245-53
Sherman, Kenneth E; Peters, Marion; Koziel, Margaret James (2007) HIV and liver disease forum: conference proceedings. Hepatology 45:1566-77