: Pertussis, caused primarily by Bordetella pertussis, is a contemporary public health problem in the US and worldwide. With >48,000 cases reported in the US in 2012, it is the least well controlled of the vaccinepreventable diseases, despite excellent coverage with acellular pertussis vaccines. While there are several hypotheses for these increases in clinical pertussis, such as increased public and medical awareness, enhanced diagnostic sensitivity and adaptation of the causal organism, it is clear that the acellular pertussis vaccines elicit protection of significantly shorter duration and diffeent type than previously used whole cell vaccines or recovery from past infection.For these reasons, the upcoming 11th International Bordetella Symposium, scheduled for April 2016 in Buenos Aires, Argentina, is particularly timely. These meetings take place on a three-four year cycle and are generally attended by 200-300 individuals (basic scientists, physicians, public health officials, vaccine manufacturers and representatives of regulatory agencies) from multiple countries; this level of participation reflects enthusiasm of the international Bordetella Research Community for this event. The major topics of discussion (see preliminary program) at this include: pertussis epidemiology and pathogenesis, immune responses and mechanisms of clearance in natural disease and following vaccine (in animals and humans) and B. pertussis strains not expressing virulence factors/vaccine antigens. Since there appear to be multiple factors (such as disparate immune response from natural disease, emergence of circulating strains not expressing vaccine antigens and possible transmission from asymptomatic hosts) contributing to the resurgence of pertussis, this meeting will provide an ideal forum for discussion of these possibilities and how to deal with the problem definitively. Thus the final session as round table discussion and consensus building exercise will be an important culmination/product from this special event with participants representing relevant areas of expertise for identifying solutions and next steps.

Public Health Relevance

Pertussis or whooping cough is no longer a disease of infants and small children and in recent years, there have been numerous outbreaks in the US, resulting in the highest number of cases since the 1950's. This resurgence is likely multifactorial in etiology, but is associated temporally with the transition from whole cell to acellular pertussi vaccines in the US and elsewhere. This international symposium is part of a series dating back to the 1960's and will provide an opportunity for physicians, scientists, regulatory and public health officials and vaccine manufacturers to address the pertussis problem collectively.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Conference (R13)
Project #
1R13AI122681-01
Application #
9053803
Study Section
Special Emphasis Panel (ZAI1-TT-M (S1))
Program Officer
Mulach, Barbara L
Project Start
2016-02-08
Project End
2017-01-31
Budget Start
2016-02-08
Budget End
2017-01-31
Support Year
1
Fiscal Year
2016
Total Cost
$5,000
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904