It is now well accepted that the immune, hematopoietic and skeletal systems have major interactions, which occur for the most part, between the bone and bone marrow. Osteoclasts, the cells that resorb bone, are important cellular mediators of skeletal homeostasis and are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines, which were first shown to regulate immune cell function, are now known to regulate bone cells and influence skeletal health. Conversely, cells in the osteoblast lineage and their cytokines are critical for the development of the hematopoietic stem cell niche and the normal development of the hematopoietic and immune cell lineages. Up until recently, scientists involved in immune or bone cell research rarely interacted in a significant way because each discipline developed independently and, for the most part, has remained separate. The fundamental hypothesis of the organizers of this conference is that progress in the field of osteoimmunology, which is the study of the interactions of bone, hematopoietic and immune cells in health and disease, will be delayed unless better communication is established between bone biologists, hematologist and immunologists. The goal of The Sixth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems is to bring together scientists from these fields in a setting that will facilitate, interactions and new collaborations and hasten progress towards understanding the interconnections of the immune, hematopoietic and skeletal system. Our five previous meetings were highly successful and well attended by 100-150 participants from all over the world.

Public Health Relevance

It is now recognized that the immune, hematopoietic and skeletal systems have major interactions, however, in the past, scientists who studied one of these disciplines often failed to fully appreciate the contribution of the other. We believe that a primary way to enhance collaborations between scientists in these previously separate disciplines is to bring the members of these fields together at a small conference in which all participants can interact freely and share ideas. Towards this goal, we will convene the Sixth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems at the Avra Hotel and Conference Center, Crete, Greece from June 17-22, 2016.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Conference (R13)
Project #
1R13AR069961-01
Application #
9117878
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Chen, Faye H
Project Start
2016-05-01
Project End
2017-04-30
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Yale University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code