This proposal is to request support for a Keystone Symposia meeting entitled Role of Inflammation in Oncogenesis, organized by Nina Bhardwaj and Giorgio Trinchieri, which will be held in Keystone, Colorado from February 7 - 12, 2010. Cancer is characterized by accelerated and uncontrolled growth, dysregulation of apoptosis, invasion and metastasis. While genetic and epigenetic mechanisms may underlie transformation, the tumor microenvironment promotes the neoplastic process. Chronic inflammation and infection, in particular, are linked to the development of cancer. Examples include the association between inflammatory bowel disease and colon cancer, Helicobacter pylori infection with gastric cancer and HPV with cervical cancer. This meeting will focus specifically on mechanisms of inflammation-induced carcinogenesis, and will bring together investigators with diverse interests and expertise - immunology, signal transduction, cancer biology and therapeutics. It is anticipated that the pairing with the concurrent Keystone Symposia meeting on Molecular and Cellular Biology of Immune Escape in Cancer will attract a large body of scientists who share a common interest in cancer pathogenesis, inflammation and mechanisms underlying immune evasion. The goal of the meeting is to enhance discussion, foster collaborations, report on new paradigms, and ultimately to develop approaches that will modulate inflammation-associated tumor progression.

Public Health Relevance

Recent studies are shedding a new light on the way in which innate resistance, as an integral part of inflammation, participates in oncogenesis and tumor surveillance. The goal of the Keystone Symposia meeting on Role of Inflammation in Oncogenesis is to bring together investigators from many distinct fields in order to facilitate new ideas regarding the means by which inflammation impacts tumor initiation and progression. The science discussed here has the potential to seed the generation of the next cohort of anti-cancer diagnostics and therapeutics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Conference (R13)
Project #
1R13CA144225-01
Application #
7799468
Study Section
Special Emphasis Panel (ZCA1-PCRB-G (P1))
Program Officer
Duglas-Tabor, Yvonne
Project Start
2010-02-01
Project End
2011-01-31
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
1
Fiscal Year
2010
Total Cost
$5,000
Indirect Cost
Name
Keystone Symposia
Department
Type
DUNS #
079780750
City
Silverthorne
State
CO
Country
United States
Zip Code
80498