Support is requested for a Keystone Symposia meeting entitled Endoderm Lineages in Development and Disease, organized by Lori Sussel, Hans-Willem E. Snoeck, James M. Wells and Aaron M. Zorn. The meeting will be held in Keystone, Colorado from February 8-13, 2015. The endoderm gives rise to a vast array of highly specialized epithelial cell types lining the respiratory and gastrointestinal tracts and contributes to associated organs such as thyroid, thymus, lungs, liver, biliary system and pancreas. Basic studies of endoderm organ development and postnatal function have revealed the molecular basis of human congenital diseases, have identified new regenerative pathways, and have made it possible to grow endoderm organ tissues in vitro. While endoderm organs vary in their form and function, there are many shared mechanisms that govern the development and homeostasis of these organs. This Keystone Symposia meeting on Endoderm Lineages in Development and Disease will highlight recent advances in our understanding of endoderm organ development during embryogenesis and how this knowledge has led to successful efforts at generating human endoderm organ cells and tissues from pluripotent stem cells. The topic of this meeting fits perfectly with the NICHD's mission to "elucidate the biochemical, molecular biological, genetic, and cellular mechanisms of embryonic development and determine how dysfunction of each of these processes lead to birth defects and disease."

Public Health Relevance

Diseases affecting endodermal organ function impact hundreds of millions of people every year. The lack of interaction between investigators studying different endoderm organ systems (e.g. pulmonary biologists and gastroenterologists) presents a major bottleneck because advances in one field are often slow to translate to others. The Keystone Symposia meeting on Endoderm Lineages in Development and Disease will break down these barriers by bringing together researchers that span the different endoderm organ systems to compare and contrast molecular mechanisms, experimental approaches, and new approaches towards translating basic research.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Conference (R13)
Project #
1R13HD081875-01
Application #
8785383
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Javois, Lorette Claire
Project Start
2014-08-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$6,000
Indirect Cost
Name
Keystone Symposia
Department
Type
DUNS #
079780750
City
Silverthorne
State
CO
Country
United States
Zip Code
80498