Stem Cells and Cell Therapies in Lung Biology and Diseases Repair and regeneration of diseased lung with stem cells is an exciting potential therapeutic approach for a variety of lung diseases. Increasing information suggests that cells normally not resident in the lung can be utilized to impair lung injury and also to induce repair and remodeling after injury. In parallel, there has been a surge in bioengineering studies investigating use of artificial and de-cellularized lung matrices as framework for three-dimensional lung regeneration. The combination of these studies with those utilizing stem cells and/or cell therapies is a promising rapidly developing direction but one that is still in its infancy. These studies have been further paralleled by significant increases in understanding the molecular and cellular events by which stem and/or progenitor cells resident in the lung participate in both lung development and in repair and remodeling after lung injury. We have held three previous conferences at the University of Vermont in July 2005, """"""""Adult Stem Cells, Lung Biology, and Lung Disease"""""""", sponsored by the NHBLI and Cystic Fibrosis Foundation;July 2007 """"""""Stem Cells and Cell Therapies in Lung Biology and Disease"""""""", sponsored by the NHLBI through an R13 conference grant as well as by the Alpha 1 Antitrypsin Foundation and Pulmonary Fibrosis Foundation;and July 2009 """"""""Stem Cells and Cell Therapies in Lung Biology and Disease"""""""", sponsored by the NHLBI through an R13 conference grant as well as by the Alpha 1 Antitrypsin Foundation, Emory Center for Respiratory Health, LAM Treatment Alliance, and Pulmonary Fibrosis Foundation that brought together relevant investigators as well as interested junior faculty and trainees to debate and discuss issues in this rapidly moving field. These conferences have been very successful and have both stimulated the field and resulted in a series of guidelines for basic and translation research to be utilized by both investigators and by funding agencies. As studies of stem cell and cell therapies for lung diseases continues to move at a rapid pace, we propose to again convene the relevant investigators as well as representatives from the NHLBI, FDA, and non-profit Respiratory Disease Foundations to again debate and discuss current issues. One area in particular to be discussed is the balance between basic and translational research and the role of clinical trials, particularly as there have now been clinical trials of stem cells for pulmonary hypertension and for COPD. As in the previous conferences, junior investigators and trainees (graduate, post-doctoral, fellow) will be particularly targeted for inclusion in both conference discussions as well as in poster sessions. As a continuing feature, trainees will be able to compete for an increased number of travel awards based on blinded review of poster abstracts. The conference is planned for July 2011 at the University of Vermont. Enthusiasm is already high among potential participants. We anticipate that this conference will again foster extensive discussion and debate and will significantly guide the directions taken in basic and clinical research of stem cells and cell therapies for lung diseases.

Public Health Relevance

Stem Cells and Cell Therapies in Lung Biology and Diseases Repair and regeneration of diseased lung with stem cells is a rapidly moving field and an exciting potential therapeutic approach for a variety of lung diseases. We propose a conference in July 2011 on Stem Cells and Cell Therapies in Lung Biology and Diseases. This conference will convene relevant experts along with interested junior investigators and trainees to discuss and debate current issues in the field and to craft guidelines for basic and translational research and for funding agencies supporting this research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Conference (R13)
Project #
2R13HL097533-02
Application #
8203946
Study Section
Special Emphasis Panel (ZHL1-CSR-V (M1))
Program Officer
Blaisdell, Carol J
Project Start
2009-07-01
Project End
2012-06-30
Budget Start
2011-07-15
Budget End
2012-06-30
Support Year
2
Fiscal Year
2011
Total Cost
$30,099
Indirect Cost
Name
University of Vermont & St Agric College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Weiss, Daniel J; Chambers, Daniel; Giangreco, Adam et al. (2015) An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases. Ann Am Thorac Soc 12:S79-97
Weiss, Daniel J (2013) Stem cells, cell therapies, and bioengineering in lung biology and diseases. Comprehensive review of the recent literature 2010-2012. Ann Am Thorac Soc 10:S45-97
Weiss, Daniel J; Bates, Jason H T; Gilbert, Thomas et al. (2013) Stem cells and cell therapies in lung biology and diseases: conference report. Ann Am Thorac Soc 10:S25-44
Weiss, Daniel J; Bertoncello, Ivan; Borok, Zea et al. (2011) Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc 8:223-72