This proposal requests support for a Keystone Symposia meeting entitled Angiogenesis: Advances in Basic Science and Therapeutic Applications, organized by Napoleone Ferrara, Anne C. Eichmann and Kenneth Walsh, which will be held in Snowbird, Utah from January 16 - 21, 2012. Much progress has been made in the identification of key signaling pathways regulating blood vessel development. There is also evidence that various stromal cell types participate in normal and pathological angiogenesis in a tissue- or context-specific fashion. However, many important molecular and biological questions regarding these processes remain unanswered. In addition, several angiogenesis inhibitors have been approved by the FDA as therapy for cancer or intraocular neovascular disorders. Perhaps some of the most successful applications of anti- angiogenic therapy are in age-related macular degeneration and other intraocular neovascular diseases, although such findings have been rarely presented outside specialized meetings. The Keystone Symposia meeting on Angiogenesis: Advances in Basic Science and Therapeutic Applications will critically examine the latest basic science on the regulation of angiogenesis in health and disease;discuss the lessons from clinical trials in cancer and intraocular neovascular disorders;and identify novel therapeutic targets. In addition, a renewed interest in therapeutic angiogenesis by tissue-engineering or stem cell-based approaches will be discussed.

Public Health Relevance

Angiogenesis - the process of developing new blood vessels - is a central player in cancer, intraocular neovascular diseases, cardiovascular diseases, intraocular diseases, various immunological and even neurological disorders. Recent advances in developmental biology, genetics and signaling are leading to a new understanding of how blood vessels are forming, as well as new ideas for stimulating and inhibiting this process to treat disease. The Keystone Symposia meeting on Angiogenesis: Advances in Basic Science and Therapeutic Applications will critically examine the latest basic science on the regulation of angiogenesis in health and disease;discuss the lessons from clinical trials in cancer and intraocular neovascular disorders;and identify novel therapeutic targets.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Conference (R13)
Project #
1R13HL110545-01
Application #
8205061
Study Section
Special Emphasis Panel (ZHL1-CSR-V (M1))
Program Officer
Gao, Yunling
Project Start
2011-07-04
Project End
2012-06-30
Budget Start
2011-07-04
Budget End
2012-06-30
Support Year
1
Fiscal Year
2011
Total Cost
$18,000
Indirect Cost
Name
Keystone Symposia
Department
Type
DUNS #
079780750
City
Silverthorne
State
CO
Country
United States
Zip Code
80498