Deer mice are the principal reservoir hosts of Sin Nombre virus, which causes the great majority of hantavirus cardiopulmonary syndrome cases in North America. Unlike human infections, which are fatal in about a third of the cases, infected deer mice do no exhibit symptoms of disease and remain otherwise healthy but persistently infected, probably for life. This project has focused on understanding the immunological events that lead to persistent infection without disease. Our efforts have demonstrated that an anti-inflammatory immune response appears to predominate at persistence and this response likely limits pathology, but also compromises viral clearance. Andes virus also infects deer mice;however, it is cleared without disease. The project will continue to examine how SNV evades the host response and why Andes virus is cleared by focusing on the genetic, molecular and cellular events during the host response to these viruses.

Public Health Relevance

Hantaviruses can cause fatal diseases in humans, including hantavirus cardiopulmonary syndrome (HCPS). Sin Nombre virus, is hosted by the deer mouse (Peromyscus maniculatus) and causes most HCPS cases in North American, while Andes virus, hosted by the long-tailed pygmy rice rat (Oligoryzomys longicaudatus), causes most HCPS cases in South America. This project will examine how deer mice fail to clear Sin Nombre virus but clear Andes virus.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
2R15AI054461-02A1
Application #
8496418
Study Section
Special Emphasis Panel (ZRG1-IMM-K (90))
Program Officer
Cassetti, Cristina
Project Start
2006-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2016-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$393,870
Indirect Cost
$93,870
Name
University of Northern Colorado
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
073410185
City
Greeley
State
CO
Country
United States
Zip Code
80639
Schountz, Tony; Prescott, Joseph (2014) Hantavirus immunology of rodent reservoirs: current status and future directions. Viruses 6:1317-35
Cautivo, Karla; Schountz, Tony; Acuña-Retamar, Mariana et al. (2014) Rapid enzyme-linked immunosorbent assay for the detection of hantavirus-specific antibodies in divergent small mammals. Viruses 6:2028-37
Schountz, Tony; Quackenbush, Sandra; Rovnak, Joel et al. (2014) Differential lymphocyte and antibody responses in deer mice infected with Sin Nombre hantavirus or Andes hantavirus. J Virol 88:8319-31
Richens, Tiffany; Palmer, Aparna D N; Prescott, Joseph et al. (2008) Genomic organization and phylogenetic utility of deer mouse (Peromyscus maniculatus) lymphotoxin-alpha and lymphotoxin-beta. BMC Immunol 9:62
Schountz, Tony; Prescott, Joseph; Cogswell, Ann C et al. (2007) Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus. Proc Natl Acad Sci U S A 104:15496-501
Schountz, Tony; Calisher, Charles H; Richens, Tiffany R et al. (2007) Rapid field immunoassay for detecting antibody to Sin Nombre virus in deer mice. Emerg Infect Dis 13:1604-7
Oko, Lauren; Aduddell-Swope, Bethany; Willis, Derall et al. (2006) Profiling helper T cell subset gene expression in deer mice. BMC Immunol 7:18