Genetically obese Drosophila has been developed by selecting for starvation resistance. This project will investigate hormonal mechanisms that cause Drosophila to accumulate excess lipids. Genomic methods will be used to identify the genetic basis for lipid storage.
This study uses genetically obese fruit flies as a model to understand genetic factors contributing to human obesity. The goal is to identify genes and hormonal pathways that cause cells and animals to accumulate fat.
|Slocumb, Melissa E; Regalado, Josue M; Yoshizawa, Masato et al. (2015) Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila. PLoS One 10:e0131275|
|Hardy, Christopher M; Birse, Ryan T; Wolf, Matthew J et al. (2015) Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol 309:R658-67|
|Masek, Pavel; Reynolds, Lauren A; Bollinger, Wesley L et al. (2014) Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster. J Exp Biol 217:3122-32|