Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
1R15NS038885-01
Application #
2881663
Study Section
Special Emphasis Panel (ZRG1-MDCN-1 (01))
Program Officer
Oliver, Eugene J
Project Start
1999-07-01
Project End
2001-11-30
Budget Start
1999-07-01
Budget End
2001-11-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Middlebury College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
020651675
City
Middlebury
State
VT
Country
United States
Zip Code
05753
Landino, Lisa M; Hagedorn, Tara D; Kennett, Kelly L (2014) Evidence for thiol/disulfide exchange reactions between tubulin and glyceraldehyde-3-phosphate dehydrogenase. Cytoskeleton (Hoboken) 71:707-18
Clark, Hillary M; Hagedorn, Tara D; Landino, Lisa M (2014) Hypothiocyanous acid oxidation of tubulin cysteines inhibits microtubule polymerization. Arch Biochem Biophys 541:67-73
Landino, Lisa M; Hagedorn, Tara D; Kim, Shannon B et al. (2011) Inhibition of tubulin polymerization by hypochlorous acid and chloramines. Free Radic Biol Med 50:1000-8
Landino, Lisa M; Brown, Carolyn M; Edson, Carolyn A et al. (2010) Fluorescein-labeled glutathione to study protein S-glutathionylation. Anal Biochem 402:102-4
Landino, Lisa M; Mall, Catherine B; Nicklay, Joshua J et al. (2008) Oxidation of 5-thio-2-nitrobenzoic acid, by the biologically relevant oxidants peroxynitrite anion, hydrogen peroxide and hypochlorous acid. Nitric Oxide 18:11-8
Landino, Lisa M; Koumas, Maria T; Mason, Courtney E et al. (2007) Modification of tubulin cysteines by nitric oxide and nitroxyl donors alters tubulin polymerization activity. Chem Res Toxicol 20:1693-700
Landino, Lisa M; Koumas, Maria T; Mason, Courtney E et al. (2006) Ascorbic acid reduction of microtubule protein disulfides and its relevance to protein S-nitrosylation assays. Biochem Biophys Res Commun 340:347-52
Landino, Lisa M; Skreslet, Tabor E; Alston, Jane A (2004) Cysteine oxidation of tau and microtubule-associated protein-2 by peroxynitrite: modulation of microtubule assembly kinetics by the thioredoxin reductase system. J Biol Chem 279:35101-5
Landino, Lisa M; Robinson, Sarah H; Skreslet, Tabor E et al. (2004) Redox modulation of tau and microtubule-associated protein-2 by the glutathione/glutaredoxin reductase system. Biochem Biophys Res Commun 323:112-7
Landino, Lisa M; Iwig, Jeffrey S; Kennett, Kelly L et al. (2004) Repair of peroxynitrite damage to tubulin by the thioredoxin reductase system. Free Radic Biol Med 36:497-506

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