Frontline physicians need reliable solutions to discriminate benign from sinister causes of dizziness. Current strategies to discriminate rely on either clinical dogma or brain computerized tomography scans, but these strategies have major flaws and are linked to misdiagnosis. Among dizziness presentations, the acute vestibular syndrome - a common category of acute-onset dizziness - is the presentation where physician decisions are the most crucial. On the one hand, the most common cause of the acute vestibular syndrome is an entirely benign peripheral vestibular viral syndrome (i.e., so called vestibular neuritis or labyrinthitis), but on the other hand the cause may be a life threatening stroke. No previous study accurately estimates basic information such as the proportion of stroke etiology in acute vestibular syndrome presentations. In addition, no previous study uses rigorous methodology to estimate the risk of stroke in an individual patient. Dizziness presentations are different from other common diagnostic dilemmas (e.g., chest pain and headache presentations) because no laboratory, electrophysiological, or neuro-imaging test is a valid and practical discriminator. Though magnetic resonance imaging (MRI) is a sensitive test for stroke, it is not a practical test to use as a discriminator in the real world emergency settings. A stroke risk score - calculated from routinely collected clinical information - may be a practical discriminator. Another potential discriminator may be the 'head thrust test,'a simple bedside test of the vestibular system. However, a stroke risk score has not been developed in this unique presentation and the head thrust test has not undergone rigorous study to determine its operating characteristics in this important clinical setting. In this R18 application, we aim to take the initial steps to optimizing value and safety of health care in acute dizziness presentations. A representative sample will be recruited and all subjects will undergo a standardized clinical evaluation blinded to MRI results. Using MRI with diffusion weighted sequences as a gold standard test for stroke etiology, we plan to develop a statistical model assessing the risk of stroke in patients presenting with the acute vestibular syndrome. Model based predictions will be based on clinical measurements and the head thrust test. The model will be used to assess the prevalence of stroke in the target patient population and the significance of the head thrust test as a risk predictor with and without clinical covariates. Using specific sensitivity and specificity tradeoff parameters, we will formulate a decision rule based on the model. Internal model validation will be performed to obtain unbiased estimates of operating characteristics. The reliability of the head thrust test will also be measured. This will help estimate model performance in future samples. This demonstration project will lay the groundwork for future multi-center validation and implementation studies that could ultimately improve the value of care and patient safety, while also fostering the appropriate use of processes of care and reducing unnecessary expenditures.
The ultimate goal of this work is to optimize value and safety in healthcare through research that will support physician decision-making. A clinical decision rule for acute dizziness presentations - developed as the result of the proposed demonstration research - could improve the quality, safety, efficiency, and effectiveness of healthcare, which is the mission of the Agency for Healthcare Research and Quality (AHRQ).
| Callaghan, Brian C; Kerber, Kevin A; Banerjee, Mousumi et al. (2016) The evaluation of distal symmetric polyneuropathy: utilisation and expenditures by community neurologists. J Neurol Neurosurg Psychiatry 87:113-4 |
| Callaghan, Brian; Kerber, Kevin; Langa, Kenneth M et al. (2015) Longitudinal patient-oriented outcomes in neuropathy: Importance of early detection and falls. Neurology 85:71-9 |
| Callaghan, Brian C; Kerber, Kevin A; Pace, Robert J et al. (2015) Headache neuroimaging: Routine testing when guidelines recommend against them. Cephalalgia 35:1144-52 |
| Kerber, Kevin A; Meurer, William J; Brown, Devin L et al. (2015) Stroke risk stratification in acute dizziness presentations: A prospective imaging-based study. Neurology 85:1869-78 |
| Callaghan, Brian C; Kerber, Kevin A; Burke, James F (2015) Headaches and neuroimaging—reply. JAMA Intern Med 175:313-4 |
| Burke, James F; Vijan, Sandeep; Chekan, Lynette A et al. (2014) Targeting high-risk employees may reduce cardiovascular racial disparities. Am J Manag Care 20:725-33 |
| Woo, Daniel; Falcone, Guido J; Devan, William J et al. (2014) Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet 94:511-21 |
| Burke, James F; Skolarus, Lesli E; Adelman, Eric E et al. (2014) Influence of hospital-level practices on readmission after ischemic stroke. Neurology 82:2196-204 |
| Callaghan, Brian C; Kerber, Kevin A; Pace, Robert J et al. (2014) Headaches and neuroimaging: high utilization and costs despite guidelines. JAMA Intern Med 174:819-21 |
| Zahuranec, Darin B; Lisabeth, Lynda D; Sánchez, Brisa N et al. (2014) Intracerebral hemorrhage mortality is not changing despite declining incidence. Neurology 82:2180-6 |
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