With an ever-growing life expectancy and senior population, costs for healthcare and assisted living for the elderly will place an unsustainable burden on the US economy as the elderly lose their functional mobility. The cost of assisted living for seniors in the US is projected to reach $248 billion by 2012. At the core of the loss of functional mobility are declines in cognitive and motor function, represented by increased intra-individual variability known as greater behavioral inconsistency. Increased neural noise is the higher occurrence of random brain activity causing greater behavioral inconsistency in the elderly. As such, scientists are continuing to seek means of attenuating age-related increases in behavioral inconsistency. Currently, the factors that attenuate these declines remain unknown, presenting a barrier to the development of targeted interventions for the clinic and community. The advantage of animal models become in studies of aging is their shorter lifespan that allows the scientist to obtain outcome data more rapidly. Yet, behavioral inconsistency has not been studied in animal models. Recent theorizations propose that animals housed in enriched experimental environments exhibit smaller age-related increases in neural noise during the aging process. "Enriched" animals that are housed in groups have the opportunity for social interaction and an environment that is varied over the experimental period with toys and food locations being changed frequently. However, the specific source of the benefits of the environment is still being debated, as enriched environments positively affect aging in a manner that cannot be replicated by socialization or exercise alone. It is thus a logical question to ask whether the increased opportunity to engage in different movement patterns provides the positive effects of enriched environments.
Our specific aim i s to test the hypothesis that greater variance in the movement patterns that one engages in is a primary source of the benefits of environmental enrichment. We will connect the effects of aging on variability in neural and motor activity with that of variety of motor activities afforded by the environment. This study will be conducted by an interdisciplinary research team from Kinesiology, Physics, and Neuroscience to examine the complex scientific problem of aging. Our study has the potential to achieve a significant scientific breakthrough due to its many innovations. The results would show that a key component to healthy aging is to continually acquire new movement skills throughout the lifespan rather than physical activity alone. Interventions that seek to slow age-related declines in cognition and action have focused primarily on maintaining existing function. Successful completion of this study would provide the evidence-base for continually introducing new movement skills to seniors, a process that could be easily implemented through community programs.

Public Health Relevance

With people over 65 years becoming proportionally the largest age bracket in America, this study is relevant to nearly an eighth of the entire nation. Successful completion of this study will show that continually engaging in a greater variety of different movement skills has a protective effect against neural and motor declines in aging, a result that can be directly translated to clinic and community. Maintaining cognitive and movement capabilities are especially relevant to public health, as they are essential components of functional mobility, which lies at the core of quality of life in the elderly.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AG039818-02
Application #
8281430
Study Section
Aging Systems and Geriatrics Study Section (ASG)
Program Officer
Chen, Wen G
Project Start
2011-06-15
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2012
Total Cost
$157,850
Indirect Cost
$55,350
Name
Indiana University Bloomington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Hong, S Lee; Estrada-Sánchez, Ana María; Barton, Scott J et al. (2016) Early exposure to dynamic environments alters patterns of motor exploration throughout the lifespan. Behav Brain Res 302:81-7
Hong, S Lee; Longo, Kenneth A; Gosney, Elahu et al. (2014) Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model. J Gerontol A Biol Sci Med Sci 69:274-81
Estrada-Sánchez, Ana M; Rebec, George V (2013) Role of cerebral cortex in the neuropathology of Huntington's disease. Front Neural Circuits 7:19
Rebec, George V (2013) Dysregulation of corticostriatal ascorbate release and glutamate uptake in transgenic models of Huntington's disease. Antioxid Redox Signal 19:2115-28
Estrada-Sánchez, Ana María; Barton, Scott J; Burroughs, Courtney L et al. (2013) Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14). PLoS One 8:e84537
Hong, S Lee; Barton, Scott J; Rebec, George V (2012) Altered neural and behavioral dynamics in Huntington's disease: an entropy conservation approach. PLoS One 7:e30879
Hong, S Lee; Rebec, George V (2012) A new perspective on behavioral inconsistency and neural noise in aging: compensatory speeding of neural communication. Front Aging Neurosci 4:27
Hong, S Lee; Rebec, George V (2012) Biological sources of inflexibility in brain and behavior with aging and neurodegenerative diseases. Front Syst Neurosci 6:77
Hong, S Lee; Cossyleon, Desirée; Hussain, Wajeeha A et al. (2012) Dysfunctional behavioral modulation of corticostriatal communication in the R6/2 mouse model of Huntington's disease. PLoS One 7:e47026
Hong, S Lee; Barton, Scott J; Rebec, George V (2012) Neural correlates of unpredictability in behavioral patterns of wild-type and R6/2 mice. Commun Integr Biol 5:259-61

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