The majority of older adults suffer multiple chronic conditions (MCCs): two-thirds of Medicare beneficiaries possess two or more MCCs, and 1 in 10 suffer 6 or more MCCs. As a result, older adults utilize 7 or more unique chronic medications annually. Thus, medication adherence, """"""""the extent to which a person's behavior coincides with medical or health advice"""""""", becomes particularly problematic in older adults with MCCs due to their greater exposure to multiple diseases and pharmacologic treatments. Poor medication adherence is implicated in clinically important and largely preventable health outcomes, including emergency department visits and hospitalizations, mortality, and medical costs. This study establishes the foundation needed to understand the management of two highly prevalent and costly conditions in older adults: chronic obstructive pulmonary disease (COPD) and depression. We focus on these two chronic, highly comorbid conditions because of their high prevalence, high costs, and their responsiveness to pharmacologic medication use and adherence. The objective of this study is to conduct research that informs our understanding of the cyclical relationships between depression and COPD-and the comparative effectiveness of treating each of these conditions-on important patient outcomes in older adults with COPD and depression. Using 2006-2011 Chronic Condition Data Warehouse (CCW) data, a nationally-representative Medicare administrative dataset of inpatient, outpatient, and pharmaceutical claims, we apply novel marginal structural modeling techniques to longitudinal analytic files. We will address the following three study aims:
Aim 1) Test whether comorbid depression influences use of and adherence to necessary maintenance medications used to treat COPD;2) Among Medicare beneficiaries with COPD and depression, test whether use of and adherence to antidepressant medications influences use of and adherence to necessary maintenance medications for COPD;and 3) Among Medicare beneficiaries with COPD and comorbid depression treated for depression, test whether antidepressant and/or COPD medication adherence reduces hospitalization, medical costs, and mortality. This study will produce the first longitudinal and nationally-representative estimates of depression incidence and treatment adherence in an older adult cohort diagnosed with COPD and depression, as well as improve our understanding of how depression treatment influences COPD maintenance medication use and adherence, and how COPD and depression treatment jointly influence important patient outcomes. The expected outcomes of this research are multiple, and include providing the knowledge needed to reduce preventable adverse outcomes, evaluate the effectiveness of depression treatment on important patient-relevant outcomes, and to demonstrate a sound methodological approach transferable to observational studies of other MCC combinations in Medicare and other available secondary databases.

Public Health Relevance

Although chronic obstructive pulmonary disease (COPD) and depression are two of the most common chronic conditions in older adults, we have little understanding of how best to manage the treatment of individuals with both conditions. Using a large sample of older adults with COPD and depression, study findings will improve our understanding of how antidepressant adherence influences COPD medication adherence, and whether adherence to medications used for both conditions prevents unnecessary hospitalizations, lowers medical costs, and reduces premature mortality.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Exploratory/Developmental Grants (R21)
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Special Emphasis Panel (ZAG1)
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Salive, Marcel
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University of Maryland Baltimore
Schools of Pharmacy
United States
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Wei, Yu-Jung; Simoni-Wastila, Linda; Albrecht, Jennifer S et al. (2018) The association of antidepressant treatment with COPD maintenance medication use and adherence in a comorbid Medicare population: A longitudinal cohort study. Int J Geriatr Psychiatry 33:e212-e220
Albrecht, Jennifer S; Khokhar, Bilal; Huang, Ting-Ying et al. (2017) Adherence and healthcare utilization among older adults with COPD and depression. Respir Med 129:53-58
Albrecht, Jennifer S; Park, Yujin; Hur, Peter et al. (2016) Adherence to Maintenance Medications among Older Adults with Chronic Obstructive Pulmonary Disease. The Role of Depression. Ann Am Thorac Soc 13:1497-504
Albrecht, Jennifer S; Huang, Ting-Ying; Park, Yujin et al. (2016) New episodes of depression among Medicare beneficiaries with chronic obstructive pulmonary disease. Int J Geriatr Psychiatry 31:441-9
Verceles, Avelino C; Weiler, Bethany; Koldobskiy, Dafna et al. (2015) Association Between Vitamin D Status and Weaning From Prolonged Mechanical Ventilation in Survivors of Critical Illness. Respir Care 60:1033-9