Abstract

This proposal examines the role of the herpes simplex virus (HSV) IgG Fc receptor (FcR) in immune evasion. The goals of the proposal are to: (1) demonstrate the biologic significance of the HSV-1 FcR in vivo. This will be done using FcR mutant and rescued viruses. (2) Define the functional domains involved in HSV-1 and HSV-2 FcR activity. Mapping studies will explore the role of HSV-1 gI and HSV-2 gE and gI in FcR-mediated immune evasion. (3) Block HSV FcR-mediated immune evasion. The investigators propose a series of vaccine candidates designed to induce antibodies that will block FcR activity and hopefully improve HSV vaccine efficacy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
2R21AI033063-06A1
Application #
2661091
Study Section
Experimental Virology Study Section (EVR)
Project Start
1992-07-01
Project End
1998-09-29
Budget Start
1997-09-30
Budget End
1998-09-29
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104