Public Health Relevance

My lab demonstrated that one Igk allele directs one Igh allele to a common pericentromeric cluster; where thetwo transiently associate; and that pairing of the two loci in this repressive nuclear compartment at the pro- topre-B cell transition induces decontraction of the Igh locus; which is important for establishing allelic exclusionand preventing ongoing cleavage. Intriguingly; we have now discovered that Ig? mRNA is involved in thisregulation. In this application we aim to identify the salient features by which Ig? mRNA alters accessibility tocontrol two important aspects of recombination: allelic exclusion and coordinate rearrangement of the Igh andIgk loci.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AI107069-02
Application #
8670698
Study Section
Cellular and Molecular Immunology - B Study Section (CMIB)
Program Officer
Nasseri, M Faraz
Project Start
2013-06-05
Project End
2015-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$254,250
Indirect Cost
$104,250
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016