Malaria is a major health problem throughout the tropical world and is transmitted by a variety of Anopheles mosquitoes. Core vector control interventions consist of indoor residual spraying of insecticides and long- lasting insecticidal nets. These are logical strategies in areas where the primary vector species feed at night on people sleeping in their houses and where mosquitoes rest inside the house after blood-feeding. But in Central America, much of the malaria transmission is due to malaria vectors that are exophagic (i.e., prefer to bite outdoors), exophilic (i.e., prefer to remain outdoors), and zoophaghic (i.e., as likely to feed on non-humans as humans). To control mosquitoes with these behavioral characteristics requires a different approach. This proposal addresses the control of zoophagic vectors. Hypothesis: Targeted use of endectocides in peridomestic livestock can significantly reduce the survival and longevity of zoophagic Anopheles vectors that feed on treated cattle. Because zoophagic vectors are responsible for much of the malaria transmission in Central America, malaria transmission will be reduced in areas where endectocides are given to livestock. This proposal will determine if endectocides, when administered to cattle, reduces the survival and fecundity of zoophagic malaria vectors in Central America. Significance: If experimental results support the hypothesis, then it is probable that malaria transmission can be reduced in areas where mass drug administration (MDA) of endectocides in livestock is instituted. The logical next step in determining the real-world significance of this approach would be to conduct longitudinal studies to monitor zoophagic vector abundance within rural areas of Central America before and after the institution of endectocidal MDA of local livestock herds.

Public Health Relevance

Endectocides are chemicals that are widely used in the livestock industry to control parasites such as intestinal nematodes, ticks, mange mites, lice, and cattle grub. When ingested by mosquitoes in a bloodmeal, endectocides have also been shown to reduce the survival and fecundity of Anopheles malaria vectors. Use of endectocides in peridomestic livestock may simultaneously hasten malaria eradication, control ticks, and boost feed-conversion for livestock in Central America. These outcomes provide human health benefits.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AI119771-02
Application #
9408615
Study Section
Vector Biology Study Section (VB)
Program Officer
Costero-Saint Denis, Adriana
Project Start
2017-01-05
Project End
2018-12-31
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of North Dakota
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
102280781
City
Grand Forks
State
ND
Country
United States
Zip Code
58202