Abstract

Public Health Relevance

Carbohydrates that adorn the surface of pathogenic bacteria constitute good targets for antibodies that coat (opsonize) the bacteria and lead to their destruction by immune effector cells. However, immunization with carbohydrates tends to lead to poor B cell memory and short- lived, low affinity antibody responses. Our hypothesis is that activation of Natural Killer T (NKT) cells and NKT follicular helper (NKTfh) cells at the time of immunization with carbohydrate antigens may circumvent limitations on the antibody response and therefore lead to improved vaccines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AI125708-01
Application #
9162107
Study Section
Cellular and Molecular Immunology - A Study Section (CMIA)
Program Officer
Ranallo, Ryan
Project Start
2016-07-01
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
$222,000
Indirect Cost
$72,000

  Institution

Name
University of Oklahoma Health Sciences Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104