Public Health Relevance

Long non-coding RNAs (lncRNAs) have recently emerged as a key level of regulation and complexity in innate immunity through many different mechanisms ranging from activating or repressing NF-kB signaling1, regulating TLR signaling2, and altering chromatin modifications3,4. Using a combination of an in silico computational platform, together with rational experimental perturbations, we have identified lncRNA ZFAS1 and its SNORDs as putative regulators of cytosolic sensing on nucleic acids. We seek to further characterize the roles and functions of the ncRNAs both in vitro and in vivo contexts of viral infection and nucleic acid sensing.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AI147201-01
Application #
9824156
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Lane, Mary Chelsea
Project Start
2019-09-01
Project End
2021-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032