We propose to synthesize multifunctional drug-loaded microbubbles for image-guided regional and systemic epigenetic therapies in cancer. The proposed research targets the following specific aims: (1) synthesis, characterization, and optimization of multifunctional drug-loaded microbubbles;(2) microbubble-assisted synergistic epigenetic therapies with ultrasound and fluorescence imaging guidance. The research is designed to verify the following major hypotheses: (1) microbubble-assisted regional epigenetic therapy in combination with PI3K/AKT signaling inhibition will significantly enhance the anti-cancer synergy;(2) systemic delivery of combinatory epigenetic therapies by tumor-targeting microbubbles will increase the therapeutic efficiency, reduce the therapeutic dose requirement, and minimize the systemic side effect. The proposed research paves the way toward an image-guided closed-loop schema for synergistic epigenetic therapies. The project is initiated by a team of researchers with multidisciplinary expertise in cancer detection, molecular imaging, cancer pharmaceutics, epigenetic therapy, drug delivery, microfabrication, and biomedical imaging. Clinical safety and efficacy have been considered at the early stage of the project to facilitate the future clinical translation from the benchtop to the bedside.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21CA159077-02
Application #
8334548
Study Section
Developmental Therapeutics Study Section (DT)
Program Officer
Tandon, Pushpa
Project Start
2011-09-19
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$158,484
Indirect Cost
$49,734
Name
Ohio State University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210